{"created":"2023-06-20T14:46:16.894045+00:00","id":13831,"links":{},"metadata":{"_buckets":{"deposit":"c7c20e0f-8da7-485c-a02b-3779fd142d9f"},"_deposit":{"created_by":1,"id":"13831","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13831"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013831","sets":["1543:1633:1647","1887:1891"]},"author_link":["127009","127013","127015","127006","127012","127008","127011","127007","127010","127014"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Proteome analysis of the cell response to X-ray irradiation and its changes by aging"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"79","bibliographicPageStart":"76","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第20回　平成15年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Twentieth Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Reactive oxygen species induced by radiation such as X-rays give various types of oxidative damage. However, when radiation dose is low, it causes stimulative effects on cells like the radiation adaptive response for cell growth. To study the variant expressions of proteins caused by a high or low radiation dose, the effect of X-rays on the expression of proteins in cultured glial cells was examined by proteome analysis. When glial cells were exposed to a high dose of 5 Gy, the relative abundance of 2 protein spots changed on 2-D gels. On the other hand, when cells were exposed to a low dose of 0.1 Gy, the relative abundance of one protein spot, different from one induced by 5 Gy, changed on 2-D gels. These protein spots were identified by MALDI-TOF mass spectrometry after digestion by trypsin. One of 2 spots which were changed by 5 Gy was identified as peroxiredoxin 2, and it increased with time until at least 24 hours after irradiation. It was also examined whether these protein spots would change by aging.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0046917026","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京都老人総合研究所"},{"subitem_text_value":"東京都老人総合研究所"},{"subitem_text_value":"東京都老人総合研究所"},{"subitem_text_value":"芝浦工業大学"},{"subitem_text_value":"東京都老人総合研究所"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Tokyo Metropolitan Institute of Gerontology"},{"subitem_text_language":"en","subitem_text_value":"Tokyo Metropolitan Institute of Gerontology"},{"subitem_text_language":"en","subitem_text_value":"Tokyo Metropolitan Institute of Gerontology"},{"subitem_text_language":"en","subitem_text_value":"Shibaura Institute of Technology"},{"subitem_text_language":"en","subitem_text_value":"Tokyo Metropolitan Institute of Gerontology"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加納, まゆみ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三浦, ゆり"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"戸田, 年総"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"浦野, 四郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 捷三"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kano, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Yuri","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toda, Toshifusa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Urano, Shiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Shozo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"X線照射","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテオーム解析","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞応答","subitem_subject_scheme":"Other"},{"subitem_subject":"加齢","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化","subitem_subject_scheme":"Other"},{"subitem_subject":"タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線量","subitem_subject_scheme":"Other"},{"subitem_subject":"マススペクトロスコピー","subitem_subject_scheme":"Other"},{"subitem_subject":"X-ray irradiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"proteome analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell response","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radiation dosage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mass spectroscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"X線照射による細胞応答とその加齢変化のプロテオーム解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"X線照射による細胞応答とその加齢変化のプロテオーム解析"}]},"item_type_id":"5","owner":"1","path":["1647","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13831","relation_version_is_last":true,"title":["X線照射による細胞応答とその加齢変化のプロテオーム解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T05:44:04.890292+00:00"}