@inproceedings{oai:jaxa.repo.nii.ac.jp:00013909,
 author = {喜多, 和子 and 菅谷, 茂 and 相澤, 舞 and Zhai, Ling and 和野, 千枝子 and 唐田, 清伸 and 鈴木, 信夫 and Kita, Kazuko and Sugaya, Shigeru and Aizawa, Mai and Zhai, Ling and Wano, Chieko and Karata, Kiyonobu and Suzuki, Nobuo},
 book = {宇宙利用シンポジウム　第19回　平成14年度, Space Utilization Research: Proceedings of the Nineteenth Space Utilization Symposium},
 month = {Feb},
 note = {A major issue in radiation and space biology is whether gene expression levels are altered in cells exposed to gravity-changing stress. In the present study, genes up- or down-regulated in radiation-sensitive human RSa cells cultured under gravity-changing conditions, were identified using a PCR-based mRNA differential display method. Exposure of cells to gravity-changing stress was performed by free-fall with a drop-shaft facility. Among the candidates for gravity-changing stress-responsive genes obtained by the differential display analysis, the translocation-associated membrane protein (TRAM) and lactate dehydrogenase A (LDH-A) genes were confirmed by Northern blotting analysis to exhibit early increased expression. Thus, TRAM and LDH-A were found to be candidates for the genes which play a role in the cellular response to gravity-changing stress. TRAM is an endoplasmic reticulum (ER) stress protein, therefore, it is also suggested that ER is a candidate for cellular organs sensitive to gravity-changing stress., 資料番号: AA0045438002},
 pages = {3--5},
 publisher = {宇宙科学研究所, The Institute of Space and Astronautical Science (ISAS)},
 title = {重力変動ストレスからのヒト遺伝子防御システム:小胞体ストレスタンパク質の関与},
 year = {2003}
}