{"created":"2023-06-20T14:46:22.032997+00:00","id":13909,"links":{},"metadata":{"_buckets":{"deposit":"aaad5517-8ea0-4f0b-b311-84a0683188fc"},"_deposit":{"created_by":1,"id":"13909","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13909"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013909","sets":["1543:1633:1648","1887:1891"]},"author_link":["127734","127743","127733","127737","127740","127738","127730","127731","127732","127741","127736","127739","127735","127742"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Gene protection system in human cells from gravity-changing stress: Involvement of an ER stress protein"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"3","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第19回　平成14年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Nineteenth Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"A major issue in radiation and space biology is whether gene expression levels are altered in cells exposed to gravity-changing stress. In the present study, genes up- or down-regulated in radiation-sensitive human RSa cells cultured under gravity-changing conditions, were identified using a PCR-based mRNA differential display method. Exposure of cells to gravity-changing stress was performed by free-fall with a drop-shaft facility. Among the candidates for gravity-changing stress-responsive genes obtained by the differential display analysis, the translocation-associated membrane protein (TRAM) and lactate dehydrogenase A (LDH-A) genes were confirmed by Northern blotting analysis to exhibit early increased expression. Thus, TRAM and LDH-A were found to be candidates for the genes which play a role in the cellular response to gravity-changing stress. TRAM is an endoplasmic reticulum (ER) stress protein, therefore, it is also suggested that ER is a candidate for cellular organs sensitive to gravity-changing stress.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0045438002","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙科学研究所"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"The Institute of Space and Astronautical Science (ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"千葉大学 大学院医学研究院"},{"subitem_text_value":"千葉大学 大学院医学研究院"},{"subitem_text_value":"千葉大学 大学院医学研究院"},{"subitem_text_value":"千葉大学 大学院医学研究院"},{"subitem_text_value":"千葉大学 大学院医学研究院"},{"subitem_text_value":"千葉大学 大学院医学研究院"},{"subitem_text_value":"千葉大学 大学院医学研究院"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Chiba University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Chiba University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Chiba University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Chiba University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Chiba University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Chiba University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Chiba University Graduate School of Medicine"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"喜多, 和子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"菅谷, 茂"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"相澤, 舞"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhai, Ling"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"和野, 千枝子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"唐田, 清伸"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 信夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kita, Kazuko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugaya, Shigeru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aizawa, Mai","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhai, Ling","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wano, Chieko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Karata, Kiyonobu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Nobuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"遺伝子発現","subitem_subject_scheme":"Other"},{"subitem_subject":"宇宙生物学","subitem_subject_scheme":"Other"},{"subitem_subject":"落下塔","subitem_subject_scheme":"Other"},{"subitem_subject":"ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"微小重力","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子防御システム","subitem_subject_scheme":"Other"},{"subitem_subject":"gene expression","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"exobiology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"drop tower","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microgravity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gene protection system","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"重力変動ストレスからのヒト遺伝子防御システム:小胞体ストレスタンパク質の関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"重力変動ストレスからのヒト遺伝子防御システム:小胞体ストレスタンパク質の関与"}]},"item_type_id":"5","owner":"1","path":["1648","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13909","relation_version_is_last":true,"title":["重力変動ストレスからのヒト遺伝子防御システム:小胞体ストレスタンパク質の関与"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T05:42:51.533390+00:00"}