{"created":"2023-06-20T14:46:22.098539+00:00","id":13910,"links":{},"metadata":{"_buckets":{"deposit":"5dded21e-bd7d-4585-8d2b-49e1d6ca5462"},"_deposit":{"created_by":1,"id":"13910","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13910"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013910","sets":["1543:1633:1648","1887:1891"]},"author_link":["127750","127751","127744","127749","127745","127748","127747","127746"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Mechanism for the adaptive response to oxidative stress in glial cells"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"8","bibliographicPageStart":"6","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第19回　平成14年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Nineteenth Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"To study cell response to low dose oxidative stress, radiation adaptive response (RAR) for cell growth and its molecular mechanism were examined using cultured glial cells. Glial cells cultured from Wistar rats were pre-treated with a low dose of X-rays (0.1 Gy) and subsequently exposed to a challenging dose of X-rays (2 Gy). The decrease of cell growth due to challenging dose of irradiation was suppressed by low dose pre-irradiation. RAR was not observed in the presence of the inhibitors of protein kinase C (PKC) or DNA-dependent protein kinase (DNAPK), and in severe combined immunodeficiency (scid) cells or ataxia-telangiectasia mutated (ATM)-knockout cells. Therefore, PKC, DNAPK, and ATM should be involved in RAR. To study the variant expressions of proteins caused by oxidative stress comprehensively, the effect of H2O2-treatment on the expressions of proteins in glial cells using proteomics was examined. The exposure to H2O2 (100 microM) changed the expression of several spots of proteins in glial cells. Spots of proteins were identified by MALDI-TOF mass spectroscopy after digestion by trypsin in gel. As a result, it was suggested that in glial cells the spot of peroxiredoxin 2 was changed by H2O2-treatment.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0045438003","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙科学研究所"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"The Institute of Space and Astronautical Science (ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京都老人総合研究所"},{"subitem_text_value":"東京都老人総合研究所"},{"subitem_text_value":"東京都老人総合研究所"},{"subitem_text_value":"東京都老人総合研究所"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Tokyo Metropolitan Institute of Gerontology"},{"subitem_text_language":"en","subitem_text_value":"Tokyo Metropolitan Institute of Gerontology"},{"subitem_text_language":"en","subitem_text_value":"Tokyo Metropolitan Institute of Gerontology"},{"subitem_text_language":"en","subitem_text_value":"Tokyo Metropolitan Institute of Gerontology"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三浦, ゆり"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加納, まゆみ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"戸田, 年総"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 捷三"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Yuri","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kano, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toda, Toshifusa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Shozo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"グリア細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"X線照射","subitem_subject_scheme":"Other"},{"subitem_subject":"マススペクトロスコピー","subitem_subject_scheme":"Other"},{"subitem_subject":"分子機構","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞成長","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA","subitem_subject_scheme":"Other"},{"subitem_subject":"glial cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"X-ray irradiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mass spectroscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"molecular mechanism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell growth","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"グリア細胞の酸化ストレス適応応答機構:細胞学的・プロテオミクス的解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"グリア細胞の酸化ストレス適応応答機構:細胞学的・プロテオミクス的解析"}]},"item_type_id":"5","owner":"1","path":["1648","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13910","relation_version_is_last":true,"title":["グリア細胞の酸化ストレス適応応答機構:細胞学的・プロテオミクス的解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T05:42:50.678057+00:00"}