{"created":"2023-06-20T14:46:22.144414+00:00","id":13911,"links":{},"metadata":{"_buckets":{"deposit":"72fa5f15-382e-4d30-9e67-62db0e147b8c"},"_deposit":{"created_by":1,"id":"13911","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13911"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013911","sets":["1543:1633:1648","1887:1891"]},"author_link":["127754","127759","127755","127758","127753","127756","127752","127757"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"A possible production of DNA clustered damage by space radiation"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"11","bibliographicPageStart":"9","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第19回　平成14年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Nineteenth Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Biological effect of heavy ions accelerated by ring cyclotron has been investigated, since heavy ions have been considered as predominantly important radiation to estimate biological effect by space radiation. Here it is reported that phosphorylated histone H2AX at ser 139 (gamma-H2AX) and NBS1, which are required for efficient DNA double-strand break repair by homologous recombination, form large undissolvable foci after exposure to accelerated Fe ions. These results suggest that unrepairable DNA clustered damage is induced by heavy ions, in vivo and gamma-H2AX and NBS1 can be used as molecular marker of DNA clustered damage.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0045438004","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙科学研究所"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"The Institute of Space and Astronautical Science (ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"理化学研究所 ラジオアイソトープ技術室"},{"subitem_text_value":"理化学研究所 ラジオアイソトープ技術室"},{"subitem_text_value":"理化学研究所 ラジオアイソトープ技術室"},{"subitem_text_value":"東京大学 大学院医学系研究科"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Institute of Physical and Chemical Research Radioisotope Technology Division"},{"subitem_text_language":"en","subitem_text_value":"Institute of Physical and Chemical Research Radioisotope Technology Division"},{"subitem_text_language":"en","subitem_text_value":"Institute of Physical and Chemical Research Radioisotope Technology Division"},{"subitem_text_language":"en","subitem_text_value":"University of Tokyo Graduate School of Medicine"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"冨田, 雅典"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"後藤, 佐智子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"谷田貝, 文夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松本, 義久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Sachiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yatagai, Fumio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Yoshihisa","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"宇宙放射線","subitem_subject_scheme":"Other"},{"subitem_subject":"DNAクラスター損傷","subitem_subject_scheme":"Other"},{"subitem_subject":"鉄イオン","subitem_subject_scheme":"Other"},{"subitem_subject":"重イオン加速器","subitem_subject_scheme":"Other"},{"subitem_subject":"生物効果","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"局所化","subitem_subject_scheme":"Other"},{"subitem_subject":"LET","subitem_subject_scheme":"Other"},{"subitem_subject":"extraterrestrial radiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA clustered damage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"iron ion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"heavy ion accelerator","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biological effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"localization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LET","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"宇宙放射線によるDNAクラスター損傷生成の可能性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"宇宙放射線によるDNAクラスター損傷生成の可能性"}]},"item_type_id":"5","owner":"1","path":["1648","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13911","relation_version_is_last":true,"title":["宇宙放射線によるDNAクラスター損傷生成の可能性"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T05:42:49.797318+00:00"}