@inproceedings{oai:jaxa.repo.nii.ac.jp:00013921,
 author = {高田, 真理 and 河西, 美代子 and Takada, Makoto and Kasai, Miyoko},
 book = {宇宙利用シンポジウム　第19回　平成14年度, Space Utilization Research: Proceedings of the Nineteenth Space Utilization Symposium},
 month = {Feb},
 note = {Metamorphosis in amphibians is the period in which the animal changes its habitat from aquatic to terrestrial and acquires antigravity mechanisms. The skin changes function quite drastically since it is located between the internal and the changed external environment. For example, amiloride-blockable epithelial Na(+) transport, which is mediated by an epithelial Na(+) channel (ENaC), develops during this period: The development of this transport is essential for the animal to adapt to terrestrial and antigravity conditions. The effects of thyroid hormone (TH), aldosterone (Aldo), prolactin (PRL), and growth hormone (GH) on this transport have been investigated by many researchers since the serum concentrations of these hormones change during metamorphosis. Study of the long-term effects of these hormones has focused on the development of the transport mediated by ENaC. This transport develops when larval skin is cultured with Aldo, but not with TH. In the presence of Aldo + PRL or Aldo + GH, the ENaC does not develop, although the non-selective cation channel (NSCC), which is a marker of larval skin, does. Aldosterone seems to be a crucial hormone in anurans for adaptation to terrestrial and antigravity conditions whereas PRL and GH seem to inhibit such adaptation. Study of the short-term effects of these hormones has focused on whether PRL and GH stimulate NSCC or ENaC. GH has no effect on either NSCC or ENaC. Although PRL has no effect on NSCC, it stimulates ENaC. How the effects of GH and PRL on the above transport differ between long-term and short-term effects requires further consideration., 資料番号: AA0045438014},
 pages = {41--44},
 publisher = {宇宙科学研究所, The Institute of Space and Astronautical Science (ISAS)},
 title = {両生類皮膚のNa輸送に対するプロラクチン、成長ホルモンの効果},
 year = {2003}
}