{"created":"2023-06-20T14:35:57.912637+00:00","id":2259,"links":{},"metadata":{"_buckets":{"deposit":"106e0bcd-aba8-4793-8102-3d37be790e98"},"_deposit":{"created_by":1,"id":"2259","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2259"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00002259","sets":["1887:1893","9:10:256:276"]},"author_link":["4732","4730","4733","4731","4735","4734"],"item_3_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Cbl-b mediated ubiquitination the downregulates the response the skeletal muscle cells to growth factors in space"}]},"item_3_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"12","bibliographicPageStart":"9","bibliographicVolumeNumber":"JAXA-RR-05-033","bibliographic_titles":[{"bibliographic_title":"宇宙航空研究開発機構研究開発報告: 平成17年度ISS科学プロジェクト室細胞生物研究プロジェクト研究開発報告"},{"bibliographic_title":"JAXA Research and Development Report: FY 2005 Cell Biology Research Project at ISS Science Project Group Research and Development Report","bibliographic_titleLang":"en"}]}]},"item_3_description_16":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、これまで多く指摘されている宇宙空間での筋萎縮に注目し、無重力による筋萎縮の新規メカニズムを実証し、その予防の可能性を探ることを目的としている。2005年度では、ISSにおけるフライト実験実施に向けた実験計画のベースライン化を目指し、次に挙げる地上予備研究を行った。(1)宇宙実験施行時に合わせたRNA回収条件を確立するため、ISOGENを用いた時とRNA Laterを用いた時の回収率の違いを検討、(2)筋萎縮に重要なユビキチンリガーゼCbl-bの発現調節機構を明らかにするため、酸化ストレスと3DクリノローテーションによるCbl-bの発現調節を解析、(3)骨芽細胞におけるユビキチンリガーゼCbl-bの機能として、ユビキチンリガーゼCbl-bが無重力による筋萎縮だけでなく、骨萎縮にも重要な働きをしていることを明らかにした。","subitem_description_type":"Abstract"}]},"item_3_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"In the present study, we hypothesize that Cbl-b mediated ubiquitination plays an important role of atrophy during spaceflight. To examine our hypothesis, we proposed and designed a flight experiment. In this section, we report that the result of studies (1) confirmation of the method of RNA extraction from flight samples, (2) analysis of Cbl-b gene expression under oxidative stress or simulated microgravity, (3) Cbl-b has a important function in bone atrophy mechanism not only muscle atrophy.","subitem_description_type":"Other"}]},"item_3_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0049199002","subitem_description_type":"Other"}]},"item_3_description_33":{"attribute_name":"レポート番号","attribute_value_mlt":[{"subitem_description":"レポート番号: JAXA-RR-05-033","subitem_description_type":"Other"}]},"item_3_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構"}]},"item_3_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Japan Aerospace Exploration Agency (JAXA)"}]},"item_3_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1349-1113","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1192675X","subitem_source_identifier_type":"NCID"}]},"item_3_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"徳島大学 医学部"},{"subitem_text_value":"宇宙航空研究開発機構 宇宙科学研究本部"},{"subitem_text_value":"宇宙航空研究開発機構 宇宙科学研究本部"}]},"item_3_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"University of Tokushima Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency Institute of Space and Astronautical Science"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency Institute of Space and Astronautical Science"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"二川, 健"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東端, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石岡, 憲昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nikawa, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashibata, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishioka, Noriaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-15"}],"displaytype":"detail","filename":"49199002.pdf","filesize":[{"value":"620.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"49199002.pdf","url":"https://jaxa.repo.nii.ac.jp/record/2259/files/49199002.pdf"},"version_id":"8b42b8a5-69d3-4e8b-8050-c2698bce2f17"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ユビキチン化","subitem_subject_scheme":"Other"},{"subitem_subject":"萎縮","subitem_subject_scheme":"Other"},{"subitem_subject":"筋","subitem_subject_scheme":"Other"},{"subitem_subject":"Cbl-b遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"無重力","subitem_subject_scheme":"Other"},{"subitem_subject":"クリノローテーション","subitem_subject_scheme":"Other"},{"subitem_subject":"リボ核酸","subitem_subject_scheme":"Other"},{"subitem_subject":"骨芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"ユビキチンリガーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"ubiquitination","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"atrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"muscles","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cbl-b gene","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"weightlessness","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"clinorotation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ribonucleic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gene","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ubiquitin ligase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"technical report","resourceuri":"http://purl.org/coar/resource_type/c_18gh"}]},"item_title":"ユビキチンリガーゼCbl-bによる筋萎縮の新規メカニズム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ユビキチンリガーゼCbl-bによる筋萎縮の新規メカニズム"}]},"item_type_id":"3","owner":"1","path":["276","1893"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"2259","relation_version_is_last":true,"title":["ユビキチンリガーゼCbl-bによる筋萎縮の新規メカニズム"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T09:25:45.557909+00:00"}