{"created":"2023-06-20T14:54:19.949134+00:00","id":22654,"links":{},"metadata":{"_buckets":{"deposit":"32d5f17c-238a-40f5-a135-cd2df739ecc7"},"_deposit":{"created_by":1,"id":"22654","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22654"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00022654","sets":["1887:1888"]},"author_link":["212305","212294","212291","212301","212280","212286","212300","212278","212296","212302","212282","212279","212274","212288","212304","212295","212287","212290","212277","212299","212284","212297","212281","212292","212298","212289","212276","212303","212285","212283","212275","212293"],"item_7_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicVolumeNumber":"10","bibliographic_titles":[{},{"bibliographic_title":"PLoS ONE","bibliographic_titleLang":"en"}]}]},"item_7_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"To understand how humans adapt to the space environment, many experiments can be conducted on astronauts as they work aboard the Space Shuttle or the International Space Station (ISS). We also need animal experiments that can apply to human models and help prevent or solve the health issues we face in space travel. The Japanese medaka (Oryzias latipes) is a suitable model fish for studying space adaptation as evidenced by adults of the species having mated successfully in space during 15 days of flight during the second International Microgravity Laboratory mission in 1994. The eggs laid by the fish developed normally and hatched as juveniles in space. In 2012, another space experiment (Medaka Osteoclast) was conducted. Six-week-old male and female Japanese medaka (Cab strain osteoblast transgenic fish) were maintained in the Aquatic Habitat system for two months in the ISS. Fish of the same strain and age were used as the ground controls. Six fish were fixed with paraformaldehyde or kept in RNA stabilization reagent (n = 4) and dissected for tissue sampling after being returned to the ground, so that several principal investigators working on the project could share samples. Histology indicated no significant changes except in the ovary. However, the RNA-seq analysis of 5345 genes from six tissues revealed highly tissue-specific space responsiveness after a two-month stay in the ISS. Similar responsiveness was observed among the brain and eye, ovary and testis, and the liver and intestine. Among these six tissues, the intestine showed the highest space response with 10 genes categorized as oxidation-reduction processes (gene ontogeny term GO:0055114), and the expression levels of choriogenin precursor genes were suppressed in the ovary. Eleven genes including klf9, klf13, odc1, hsp70 and hif3a were upregulated in more than four of the tissues examined, thus suggesting common immunoregulatory and stress responses during space adaptation.","subitem_description_type":"Other"}]},"item_7_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"形態: カラー図版あり","subitem_description_type":"Other"}]},"item_7_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"Physical characteristics: Original contains color illustrations","subitem_description_type":"Other"}]},"item_7_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: PA1610027000","subitem_description_type":"Other"}]},"item_7_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_7_relation_25":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1371/journal.pone.0138799"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1371/journal.pone.0138799","subitem_relation_type_select":"DOI"}}]},"item_7_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_7_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東北大学大学院医学研究科"},{"subitem_text_value":"東京大学大学院新領域創成科学研究科"},{"subitem_text_value":"東京大学大学院新領域創成科学研究科"},{"subitem_text_value":"東京大学大学院新領域創成科学研究科"},{"subitem_text_value":"東京工業大学生命理工学部・大学院　生命理工学研究科"},{"subitem_text_value":"東京工業大学生命理工学部・大学院　生命理工学研究科"},{"subitem_text_value":"東京工業大学生命理工学部・大学院　生命理工学研究科"},{"subitem_text_value":"東京工業大学生命理工学部・大学院　生命理工学研究科"},{"subitem_text_value":"日本宇宙フォーラム"},{"subitem_text_value":"日本宇宙フォーラム"},{"subitem_text_value":"宇宙航空研究機構（JAXA)"},{"subitem_text_value":"宇宙航空研究機構（JAXA)"},{"subitem_text_value":"山口大学医学部大学院"},{"subitem_text_value":"山口大学医学部大学院"},{"subitem_text_value":"新潟大学大学院医歯学研究科"},{"subitem_text_value":"東京大学大学院新領域創成科学研究科"}]},"item_7_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medicine, Tohoku University"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Frontier Sciences, The University of Tokyo"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Frontier Sciences, The University of Tokyo"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Frontier Sciences, The University of Tokyo"},{"subitem_text_language":"en","subitem_text_value":"Graduated School of Bioscience and Biotechnology, Tokyo Institute of Technology"},{"subitem_text_language":"en","subitem_text_value":"Graduated School of Bioscience and Biotechnology, Tokyo Institute of Technology"},{"subitem_text_language":"en","subitem_text_value":"Graduated School of Bioscience and Biotechnology, Tokyo Institute of Technology"},{"subitem_text_language":"en","subitem_text_value":"Graduated School of Bioscience and Biotechnology, Tokyo Institute of Technology"},{"subitem_text_language":"en","subitem_text_value":"Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Yamaguchi University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Yamaguchi University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medical and Dental Sciences, Niigata University"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Frontier Sciences, The University of Tokyo,"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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正輝"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤澤, 浩一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"浜本, 義彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"寺井, 崇二"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三谷, 啓志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murata, Yasuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasuda, Takako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe-Asaka, Tomomi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oda, Shoji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mantoku, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeyama, Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chatani, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kudo, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uchida, Satoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Hiromi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanigaki, Fumiaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shirakawa, Masaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujisawa, Koichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamamoto, Yoshihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Terai, Shuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitani, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Histological and Transcriptomic Analysis of Adult Japanese Medaka Sampled Onboard the International Space Station","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Histological and Transcriptomic Analysis of Adult Japanese Medaka Sampled Onboard the International Space Station","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["1888"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-05-31"},"publish_date":"2016-05-31","publish_status":"0","recid":"22654","relation_version_is_last":true,"title":["Histological and Transcriptomic Analysis of Adult Japanese Medaka Sampled Onboard the International Space Station"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T03:17:32.325506+00:00"}