{"created":"2023-06-20T14:54:19.993223+00:00","id":22655,"links":{},"metadata":{"_buckets":{"deposit":"5bdb405c-0629-42e3-8663-169ce27ac1d9"},"_deposit":{"created_by":1,"id":"22655","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22655"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00022655","sets":["1887:1888"]},"author_link":["212314","212312","212326","212336","212325","212317","212315","212324","212329","212332","212307","212330","212331","212333","212327","212318","212339","212310","212338","212313","212311","212328","212322","212309","212321","212308","212335","212337","212320","212334","212323","212319","212316","212306"],"item_7_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicVolumeNumber":"10","bibliographic_titles":[{},{"bibliographic_title":"PLoS ONE","bibliographic_titleLang":"en"}]}]},"item_7_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Gravity change affects many immunological systems. We investigated the effects of hypergravity (2G) on murine thymic cells. Exposure of mice to 2G for three days reduced the frequency of CD4(+)CD8(+) thymocytes (DP) and mature medullary thymic epithelial cells (mTECs), accompanied by an increment of keratin-5 and keratin-8 double-positive (K5(+)K8(+)) TECs that reportedly contain TEC progenitors. Whereas the reduction of DP was recovered by a 14-day exposure to 2G, the reduction of mature mTECs and the increment of K5(+)K8(+) TEC persisted. Interestingly, a surgical lesion of the inner ear’s vestibular apparatus inhibited these hypergravity effects. Quantitative PCR analysis revealed that the gene expression of Aire and RANK that are critical for mTEC function and development were upregulated by the 3-day exposure and subsequently down-regulated by the 14-day exposure to 2G. Unexpectedly, this dynamic change in mTEC gene expression was independent of the vestibular apparatus. Overall, data suggest that 2G causes a temporary reduction of DP and a persistent reduction of mature mTECs in a vestibular system-dependent manner, and also dysregulates mTEC gene expression without involving the vestibular system. These data might provide insight on the impact of gravity change on thymic functions during spaceflight and living.","subitem_description_type":"Other"}]},"item_7_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"形態: カラー図版あり","subitem_description_type":"Other"}]},"item_7_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"Physical characteristics: Original contains color illustrations","subitem_description_type":"Other"}]},"item_7_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: PA1610028000","subitem_description_type":"Other"}]},"item_7_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_7_relation_25":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1371/journal.pone.0141650"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1371/journal.pone.0141650","subitem_relation_type_select":"DOI"}}]},"item_7_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_7_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学医科学研究所: 宇宙航空研究開発機構きぼう利用センター(JAXA)"},{"subitem_text_value":"東京大学医科学研究所: 宇宙航空研究開発機構きぼう利用センター(JAXA)"},{"subitem_text_value":"東京大学医科学研究所: 宇宙航空研究開発機構きぼう利用センター(JAXA)"},{"subitem_text_value":"東京大学医科学研究所: 宇宙航空研究開発機構きぼう利用センター(JAXA)"},{"subitem_text_value":"宇宙航空研究開発機構きぼう利用センター(JAXA): 東京大学システム疾患モデル研究センター"},{"subitem_text_value":"宇宙航空研究開発機構きぼう利用センター(JAXA): 筑波大学生命科学動物資源センター:"},{"subitem_text_value":"宇宙航空研究開発機構きぼう利用センター(JAXA): 筑波大学生命科学動物資源センター:"},{"subitem_text_value":"宇宙航空研究開発機構きぼう利用センター(JAXA): 東京医科歯科大学"},{"subitem_text_value":"宇宙航空研究開発機構きぼう利用センター: 岐阜大学大学院"},{"subitem_text_value":"東京大学医科学研究所"},{"subitem_text_value":"宇宙航空研究開発機構きぼう利用センター(JAXA)"},{"subitem_text_value":"宇宙航空研究開発機構きぼう利用センター(JAXA)"},{"subitem_text_value":"宇宙航空研究開発機構宇宙きぼう利用センター(JAXA): 東京医科歯科大学"},{"subitem_text_value":"宇宙航空研究開発機構きぼう利用センター(JAXA): 東京大学システム疾患モデル研究センター"},{"subitem_text_value":"宇宙航空研究開発機構きぼう利用センター(JAXA): 筑波大学生命科学動物資源センター:"},{"subitem_text_value":"宇宙航空研究開発機構宇宙きぼう利用センター(JAXA): 岐阜大学大学院"},{"subitem_text_value":"東京大学医科学研究所: 宇宙航空研究開発機構きぼう利用センター(JAXA)"}]},"item_7_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"The Institute of Medical Science, The University of Tokyo: Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"The Institute of Medical Science, The University of Tokyo: Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"The Institute of Medical Science, The University of Tokyo: Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"The Institute of Medical Science, The University of Tokyo: Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Center for Experimental Medicine and Systems Biology, The University of Tokyo"},{"subitem_text_language":"en","subitem_text_value":"Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Laboratory Animal Resource Center, University of Tsukuba"},{"subitem_text_language":"en","subitem_text_value":"Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Laboratory Animal Resource Center, University of Tsukuba"},{"subitem_text_language":"en","subitem_text_value":"Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Tokyo Medical and Dental University"},{"subitem_text_language":"en","subitem_text_value":"Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Gifu University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"The Institute of Medical Science, The University of Tokyo"},{"subitem_text_language":"en","subitem_text_value":"Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Tokyo Medical and Dental University"},{"subitem_text_language":"en","subitem_text_value":"Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The University of Tokyo"},{"subitem_text_language":"en","subitem_text_value":"Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Laboratory Animal Resource Center, University of Tsukuba"},{"subitem_text_language":"en","subitem_text_value":"Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Department of Physiology, Gifu University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"The Institute of Medical Science, The University of Tokyo: Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA)"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"立石, 涼介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"秋山, 伸子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮内, 真紀"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"良永, 理子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"笹沼, 寛樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"工藤, 崇"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"新保, 未来"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"篠原, 正浩"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小畑, 孝二"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井上, 純一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"白川, 正輝"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"芝, 大"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"浅原, 弘嗣"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉田, 進昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高橋, 智"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"森田, 啓之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"秋山, 泰身"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tateishi, Ryosuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akiyama, Nobuko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyauchi, Maki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshinaga, Riko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasanuma, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kudo, 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Hironobu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akiyama, Taishin","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hypergravity Provokes a Temporary Reduction in CD4+CD8+Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hypergravity Provokes a Temporary Reduction in CD4+CD8+Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["1888"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-05-31"},"publish_date":"2016-05-31","publish_status":"0","recid":"22655","relation_version_is_last":true,"title":["Hypergravity Provokes a Temporary Reduction in CD4+CD8+Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T03:17:31.438465+00:00"}