{"created":"2023-06-20T14:54:20.037502+00:00","id":22656,"links":{},"metadata":{"_buckets":{"deposit":"257b437f-be31-4973-b1bf-60a25f0074d2"},"_deposit":{"created_by":1,"id":"22656","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22656"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00022656","sets":["1887:1888"]},"author_link":["212348","212359","212355","212343","212352","212362","212341","212363","212347","212358","212356","212357","212353","523367","212354","212360","212365","212345","212340","212344","212351","523368","212342","212346","212361","212349","212350","212364"],"item_7_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-09","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"5","bibliographic_titles":[{},{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_7_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"The dipeptidyl peptidase 11 from Porphyromonas gingivalis (PgDPP11) belongs to the S46 family of serine peptidases and preferentially cleaves substrates with Asp/Glu at the P1 position. The molecular mechanism underlying the substrate specificity of PgDPP11, however, is unknown. Here, we report the crystal structure of PgDPP11. The enzyme contains a catalytic domain with a typical double β-barrel fold and a recently identified regulatory α-helical domain. Crystal structure analyses, docking studies, and biochemical studies revealed that the side chain of Arg673 in the S1 subsite is essential for recognition of the Asp/Glu side chain at the P1 position of the bound substrate. Because S46 peptidases are not found in mammals and the Arg673 is conserved among DPP11s, we anticipate that DPP11s could be utilised as targets for antibiotics. In addition, the present structure analyses could be useful templates for the design of specific inhibitors of DPP11s from pathogenic organisms.","subitem_description_type":"Other"}]},"item_7_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"形態: カラー図版あり","subitem_description_type":"Other"}]},"item_7_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"Physical characteristics: Original contains color illustrations","subitem_description_type":"Other"}]},"item_7_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: PA1610029000","subitem_description_type":"Other"}]},"item_7_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_7_relation_25":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1038/srep11151"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/srep11151","subitem_relation_type_select":"DOI"}}]},"item_7_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_7_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"長岡技術科学大学"},{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"株式会社丸和栄養食品"},{"subitem_text_value":"コンフォーカルサイエンス（株）"},{"subitem_text_value":"宇宙航空研究開発機構(JAXA)"},{"subitem_text_value":"宇宙航空研究開発機構(JAXA)"},{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"長岡技術科学大学"},{"subitem_text_value":"昭和大学"}]},"item_7_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Nagaoka University of Technology"},{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Maruwa Foods and Biosciences Inc."},{"subitem_text_language":"en","subitem_text_value":"Confocal Science Inc."},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Showa University"},{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Nagaoka University of Technology"},{"subitem_text_language":"en","subitem_text_value":"Showa University"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"阪本, 泰光"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 義之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"飯塚, 一平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"館岡, 千佳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"六本木, 沙織"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤本, 真友"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊中, 浩治"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田仲, 広明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山田, 貢"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"太田, 和敬"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"合田, 浩明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野中, 孝昌"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小笠原, 渉"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 信忠"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Yasumitsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iizuka, Ippei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tateoka, Chika","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Roppongi, Saori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto, Mayu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inaka, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Mitsugu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohta, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gouda, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nonaka, Takamasa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogasawara, Wataru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Nobutada","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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