@article{oai:jaxa.repo.nii.ac.jp:00022659,
 author = {新保, 未来 and 工藤, 崇 and 濱田, 理人 and 全, 孝静 and 今村, 優希 and 浅野, 圭吾 and 岡田, 理沙 and 綱川, 祐貴 and 水野, 聖哉 and 八神, 健一 and 石川, 千尋 and Li, Haiyan and 志賀, 隆 and 石田, 純治 and 濱田, 樹理 and 村田, 知弥 and 石丸, 友博 and 橋本, 美涼 and 深水, 昭吉 and 山根, 睦 and 伊川, 正人 and 森田, 啓之 and 篠原, 正浩 and 浅原, 弘嗣 and 秋山, 泰身 and 秋山, 伸子 and 笹沼, 寛樹 and 吉田, 進昭 and Zhou, Rui and Wang, Ying-Ying and 伊藤, 泰斗 and 國分, 優子 and 野口, 隆明 and 石嶺, 久子 and 栗崎, 晃 and 芝, 大 and 水野, 浩靖 and 白川, 正輝 and 伊藤, 尚基 and 武田, 伸一 and 高橋, 智 and Shimbo, Miki and Kudo, Takashi and Hamada, Michito and Jeon, Hyojung and Imamura, Yuki and Asano, Keigo and Okada, Risa and Tsunakawa, Yuki and Mizuno, Seiya and Yagami, Kenichi and Ishikawa, Chihiro and Li, Haiyan and Shiga, Takashi and Ishida, Junji and Hamada, Juri and Murata, Kazuya and Ishimaru, Tomohiro and Hashimoto, Misuzu and Fukamizu, Akiyoshi and Yamane, Mutsumi and Ikawa, Masahito and Morita, Hironobu and Shinohara, Masahiro and Asahara, Hiroshi and Akiyama, Taishin and Akiyama, Nobuko and Sasanuma, Hiroki and Yoshida, Nobuaki and Zhou, Rui and Wang, Ying-Ying and Ito, Taito and Kokubu, Yuko and Noguchi, Takaaki  K. and Ishimine, Hisako and Kurisaki, Akira and Shiba, Dai and Mizuno, Hiroyasu and Shirakawa, Masaki and Ito, Naoki and Takeda, Shin and Takahashi, Satoru},
 issue = {2},
 journal = {Experimental Animals},
 month = {Jan},
 note = {The Japan Aerospace Exploration Agency developed the mouse Habitat Cage Unit (HCU) for installation in the Cell Biology Experiment Facility (CBEF) onboard the Japanese Experimental Module (“Kibo”) on the International Space Station. The CBEF provides “space-based controls” by generating artificial gravity in the HCU through a centrifuge, enabling a comparison of the biological consequences of microgravity and artificial gravity of 1 g on mice housed in space. Therefore, prior to the space experiment, a ground-based study to validate the habitability of the HCU is necessary to conduct space experiments using the HCU in the CBEF. Here, we investigated the ground-based effect of a 32-day housing period in the HCU breadboard model on male mice in comparison with the control cage mice. Morphology of skeletal muscle, the thymus, heart, and kidney, and the sperm function showed no critical abnormalities between the control mice and HCU mice. Slight but significant changes caused by the HCU itself were observed, including decreased body weight, increased weights of the thymus and gastrocnemius, reduced thickness of cortical bone of the femur, and several gene expressions from 11 tissues. Results suggest that the HCU provides acceptable conditions for mouse phenotypic analysis using CBEF in space, as long as its characteristic features are considered. Thus, the HCU is a feasible device for future space experiments., 形態: 図版あり, Full name: Takeda, Shinichi, Physical characteristics: Original contains illustrations, 資料番号: PA1610032000},
 pages = {175--187},
 title = {Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies},
 volume = {65},
 year = {2016}
}