@article{oai:jaxa.repo.nii.ac.jp:00022661,
 author = {東端, 晃 and 橋爪, 藤子 and 根本, 華奈子 and 東谷, なほ子 and Etheridge, Timothy and 森, ちひろ and 原田, 俊介 and 杉本, 朋子 and Szewczyk, Nathaniel J. and 馬場, 昭次 and 最上, 善広 and 福井, 啓二 and 東谷, 篤志 and Higashibata, Akira and Hashizume, Toko and Nemoto, Kanako and Higashitani, Nahoko and Etheridge, Timothy and Mori, Chihiro and Harada, Shunsuke and Sugimoto, Tomoko and Szewczyk, Nathaniel  J. and Baba, Shoji  A. and Mogami, Yoshihiro and Fukui, Keiji and Higashitani, Atsushi},
 journal = {npj Microgravity},
 month = {Jan},
 note = {Although muscle atrophy is a serious problem during spaceflight, little is known about the sequence of molecular events leading to atrophy in response to microgravity. We carried out a spaceflight experiment using Caenorhabditis elegans onboard the Japanese Experiment Module of the International Space Station. Worms were synchronously cultured in liquid media with bacterial food for 4 days under microgravity or on a 1-G centrifuge. Worms were visually observed for health and movement and then frozen. Upon return, we analyzed global gene and protein expression using DNA microarrays and mass spectrometry. Body length and fat accumulation were also analyzed. We found that in worms grown from the L1 larval stage to adulthood under microgravity, both gene and protein expression levels for muscular thick filaments, cytoskeletal elements, and mitochondrial metabolic enzymes decreased relative to parallel cultures on the 1-G centrifuge (95% confidence interval (P less than or equal to 0.05)). In addition, altered movement and decreased body length and fat accumulation were observed in the microgravity-cultured worms relative to the 1-G cultured worms. These results suggest protein expression changes that may account for the progressive muscular atrophy observed in astronauts., 形態: カラー図版あり, Physical characteristics: Original contains color illustrations, 資料番号: PA1610036000},
 title = {Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans},
 volume = {2},
 year = {2016}
}