{"created":"2023-06-20T14:54:20.257849+00:00","id":22661,"links":{},"metadata":{"_buckets":{"deposit":"f737ac5c-f5bb-4bf9-8e80-c93fcd230d49"},"_deposit":{"created_by":1,"id":"22661","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22661"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00022661","sets":["1887:1888"]},"author_link":["212508","212505","212510","212515","212507","212519","212518","212529","212523","212513","212525","212512","212527","212509","212530","212514","212516","212522","212528","212526","212520","212517","212506","212524","212511","212521"],"item_7_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01-21","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"2","bibliographic_titles":[{},{"bibliographic_title":"npj Microgravity","bibliographic_titleLang":"en"}]}]},"item_7_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Although muscle atrophy is a serious problem during spaceflight, little is known about the sequence of molecular events leading to atrophy in response to microgravity. We carried out a spaceflight experiment using Caenorhabditis elegans onboard the Japanese Experiment Module of the International Space Station. Worms were synchronously cultured in liquid media with bacterial food for 4 days under microgravity or on a 1-G centrifuge. Worms were visually observed for health and movement and then frozen. Upon return, we analyzed global gene and protein expression using DNA microarrays and mass spectrometry. Body length and fat accumulation were also analyzed. We found that in worms grown from the L1 larval stage to adulthood under microgravity, both gene and protein expression levels for muscular thick filaments, cytoskeletal elements, and mitochondrial metabolic enzymes decreased relative to parallel cultures on the 1-G centrifuge (95% confidence interval (P less than or equal to 0.05)). In addition, altered movement and decreased body length and fat accumulation were observed in the microgravity-cultured worms relative to the 1-G cultured worms. These results suggest protein expression changes that may account for the progressive muscular atrophy observed in astronauts.","subitem_description_type":"Other"}]},"item_7_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"形態: カラー図版あり","subitem_description_type":"Other"}]},"item_7_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"Physical characteristics: Original contains color illustrations","subitem_description_type":"Other"}]},"item_7_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: PA1610036000","subitem_description_type":"Other"}]},"item_7_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Nature"}]},"item_7_relation_25":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1038/npjmgrav.2015.22"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/npjmgrav.2015.22","subitem_relation_type_select":"DOI"}}]},"item_7_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2373-8065","subitem_source_identifier_type":"ISSN"}]},"item_7_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"宇宙航空研究開発機構有人宇宙技術部門(JAXA): 鹿児島大学"},{"subitem_text_value":"鹿児島大学: 株式会社エイ・イー・エス"},{"subitem_text_value":"東北大学"},{"subitem_text_value":"東北大学"},{"subitem_text_value":"ノッティンガム大学: エクセター大学"},{"subitem_text_value":"東北大学"},{"subitem_text_value":"東北大学"},{"subitem_text_value":"宇宙航空研究開発機構有人宇宙技術部門(JAXA)"},{"subitem_text_value":"ノッティンガム大学"},{"subitem_text_value":"御茶ノ水大学"},{"subitem_text_value":"御茶ノ水大学"},{"subitem_text_value":"日本宇宙フォーラム"},{"subitem_text_value":"東北大学"}]},"item_7_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA): Kagoshima University"},{"subitem_text_language":"en","subitem_text_value":"Kagoshima University: Advanced Engineering Services Co., Ltd"},{"subitem_text_language":"en","subitem_text_value":"Tohoku University"},{"subitem_text_language":"en","subitem_text_value":"Tohoku University"},{"subitem_text_language":"en","subitem_text_value":"University of Nottingham: University of Exeter"},{"subitem_text_language":"en","subitem_text_value":"Tohoku University"},{"subitem_text_language":"en","subitem_text_value":"Tohoku University"},{"subitem_text_language":"en","subitem_text_value":"Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"University of Nottingham"},{"subitem_text_language":"en","subitem_text_value":"Ochanomizu University"},{"subitem_text_language":"en","subitem_text_value":"Ochanomizu University"},{"subitem_text_language":"en","subitem_text_value":"Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Tohoku University"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"東端, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"橋爪, 藤子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"根本, 華奈子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東谷, なほ子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Etheridge, Timothy"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"森, ちひろ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原田, 俊介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"杉本, 朋子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Szewczyk, Nathaniel J."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"馬場, 昭次"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"最上, 善広"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福井, 啓二"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東谷, 篤志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashibata, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashizume, Toko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nemoto, Kanako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashitani, Nahoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Etheridge, Timothy","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Chihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harada, Shunsuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugimoto, Tomoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Szewczyk, Nathaniel  J.","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Baba, Shoji  A.","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mogami, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukui, Keiji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashitani, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["1888"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-05-31"},"publish_date":"2016-05-31","publish_status":"0","recid":"22661","relation_version_is_last":true,"title":["Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T03:17:27.414989+00:00"}