@article{oai:jaxa.repo.nii.ac.jp:00022662,
 author = {原田, 俊介 and 橋爪, 藤子 and 根本, 華奈子 and Shao, Zhenhua and 東谷, なほ子 and Etheridge, Timothy and Szewczyk, Nathaniel J. and 福井, 啓二 and 東端, 晃 and 東谷, 篤志 and Harada, Shunsuke and Hashizume, Toko and Nemoto, Kanako and Shao, Zhenhua and Higashitani, Nahoko and Etheridge, Timothy and Szewczyk, Nathaniel  J. and Fukui, Keiji and Higashibata, Akira and Higashitani, Atsushi},
 journal = {npj Microgravity},
 month = {Apr},
 note = {Skeletal muscle wasting is a major obstacle for long-term space exploration. Similar to astronauts, the nematode Caenorhabditis elegans displays negative muscular and physical effects when in microgravity in space. It remains unclear what signaling molecules and behavior(s) cause these negative alterations. Here we studied key signaling molecules involved in alterations of C. elegans physique in response to fluid dynamics in ground-based experiments. Placing worms in space on a 1G accelerator increased a myosin heavy chain, myo-3, and a transforming growth factor-β (TGF-β), dbl-1, gene expression. These changes also occurred when the fluid dynamic parameters viscosity/drag resistance or depth of liquid culture were increased on the ground. In addition, body length increased in wild type and body wall cuticle collagen mutants, rol-6 and dpy-5, grown in liquid culture. In contrast, body length did not increase in TGF-β, dbl-1, or downstream signaling pathway, sma-4/Smad, mutants. Similarly, a D1-like dopamine receptor, DOP-4, and a mechanosensory channel, UNC-8, were required for increased dbl-1 expression and altered physique in liquid culture. As C. elegans contraction rates are much higher when swimming in liquid than when crawling on an agar surface, we also examined the relationship between body length enhancement and rate of contraction. Mutants with significantly reduced contraction rates were typically smaller. However, in dop-4, dbl-1, and sma-4 mutants, contraction rates still increased in liquid. These results suggest that neuromuscular signaling via TGF-β/DBL-1 acts to alter body physique in response to environmental conditions including fluid dynamics., 形態: カラー図版あり, Physical characteristics: Original contains color illustrations, 資料番号: PA1610037000},
 title = {Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling},
 volume = {2},
 year = {2016}
}