{"created":"2023-06-20T14:54:20.302287+00:00","id":22662,"links":{},"metadata":{"_buckets":{"deposit":"98ca225c-dfd1-40bf-8932-13467f8d1737"},"_deposit":{"created_by":1,"id":"22662","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22662"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00022662","sets":["1887:1888"]},"author_link":["212541","212545","212536","212535","212532","212534","212548","212533","212538","212540","212546","212550","212542","212543","212537","212547","212539","212544","212531","212549"],"item_7_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04-07","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"2","bibliographic_titles":[{},{"bibliographic_title":"npj Microgravity","bibliographic_titleLang":"en"}]}]},"item_7_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Skeletal muscle wasting is a major obstacle for long-term space exploration. Similar to astronauts, the nematode Caenorhabditis elegans displays negative muscular and physical effects when in microgravity in space. It remains unclear what signaling molecules and behavior(s) cause these negative alterations. Here we studied key signaling molecules involved in alterations of C. elegans physique in response to fluid dynamics in ground-based experiments. Placing worms in space on a 1G accelerator increased a myosin heavy chain, myo-3, and a transforming growth factor-β (TGF-β), dbl-1, gene expression. These changes also occurred when the fluid dynamic parameters viscosity/drag resistance or depth of liquid culture were increased on the ground. In addition, body length increased in wild type and body wall cuticle collagen mutants, rol-6 and dpy-5, grown in liquid culture. In contrast, body length did not increase in TGF-β, dbl-1, or downstream signaling pathway, sma-4/Smad, mutants. Similarly, a D1-like dopamine receptor, DOP-4, and a mechanosensory channel, UNC-8, were required for increased dbl-1 expression and altered physique in liquid culture. As C. elegans contraction rates are much higher when swimming in liquid than when crawling on an agar surface, we also examined the relationship between body length enhancement and rate of contraction. Mutants with significantly reduced contraction rates were typically smaller. However, in dop-4, dbl-1, and sma-4 mutants, contraction rates still increased in liquid. These results suggest that neuromuscular signaling via TGF-β/DBL-1 acts to alter body physique in response to environmental conditions including fluid dynamics.","subitem_description_type":"Other"}]},"item_7_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"形態: カラー図版あり","subitem_description_type":"Other"}]},"item_7_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"Physical characteristics: Original contains color illustrations","subitem_description_type":"Other"}]},"item_7_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: PA1610037000","subitem_description_type":"Other"}]},"item_7_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Nature"}]},"item_7_relation_25":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1038/npjmgrav.2016.6"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/npjmgrav.2016.6","subitem_relation_type_select":"DOI"}}]},"item_7_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2373-8065","subitem_source_identifier_type":"ISSN"}]},"item_7_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東北大学"},{"subitem_text_value":"株式会社エイ・イー・エス: 鹿児島大学"},{"subitem_text_value":"東北大学"},{"subitem_text_value":"東北大学大学院生命科学研究科"},{"subitem_text_value":"東北大学大学院生命科学研究科"},{"subitem_text_value":"エクセター大学"},{"subitem_text_value":"ノッティンガム大学"},{"subitem_text_value":"日本宇宙フォーラム"},{"subitem_text_value":"宇宙航空研究開発機構有人宇宙技術部門(JAXA): 鹿児島大学"},{"subitem_text_value":"東北大学"}]},"item_7_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Tohoku University"},{"subitem_text_language":"en","subitem_text_value":"Advanced Engineering Services: Kagoshima University"},{"subitem_text_language":"en","subitem_text_value":"Tohoku University"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Life Sciences, Tohoku University"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Life Sciences, Tohoku University"},{"subitem_text_language":"en","subitem_text_value":"University of Exeter"},{"subitem_text_language":"en","subitem_text_value":"University of Nottingham"},{"subitem_text_language":"en","subitem_text_value":"Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA): Kagoshima University"},{"subitem_text_language":"en","subitem_text_value":"Tohoku University"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"原田, 俊介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"橋爪, 藤子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"根本, 華奈子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shao, Zhenhua"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東谷, なほ子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Etheridge, Timothy"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Szewczyk, Nathaniel J."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福井, 啓二"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東端, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東谷, 篤志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harada, Shunsuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashizume, Toko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nemoto, Kanako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shao, Zhenhua","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashitani, Nahoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Etheridge, Timothy","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Szewczyk, Nathaniel  J.","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukui, Keiji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashibata, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashitani, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["1888"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-05-31"},"publish_date":"2016-05-31","publish_status":"0","recid":"22662","relation_version_is_last":true,"title":["Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T03:17:26.420513+00:00"}