{"created":"2023-06-20T14:54:22.176891+00:00","id":22705,"links":{},"metadata":{"_buckets":{"deposit":"2912bdae-1a16-47dd-a0f2-c28dda59be89"},"_deposit":{"created_by":1,"id":"22705","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22705"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00022705","sets":["1887:1888"]},"author_link":["213076","213050","213077","213071","213070","213075","213065","213058","213062","213073","213080","213072","213060","213064","213049","213059","213055","213079","213051","213066","213053","213061","213057","213069","213052","213056","213067","213074","213078","213068","213054","213063"],"item_7_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-15","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"4","bibliographic_titles":[{},{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_7_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"The dipeptidyl aminopeptidase BII (DAP BII) belongs to a serine peptidase family, S46. The amino acid sequence of the catalytic unit of DAP BII exhibits significant similarity to those of clan PA endopeptidases, such as chymotrypsin. However, the molecular mechanism of the exopeptidase activity of family S46 peptidase is unknown. Here, we report crystal structures of DAP BII. DAP BII contains a peptidase domain including a typical double b-barrel fold and previously unreported a-helical domain. The structures of peptide complexes revealed that the a-helical domain covers the active-site cleft and the side chain of Asn330 in the domain forms hydrogen bonds with the N-terminus of the bound peptide. These observations indicate that the a-helical domain regulates the exopeptidase activity of DAP BII. Because S46 peptidases are not found in mammals, we expect that our study will be useful for the design of specific inhibitors of S46 peptidases from pathogens.","subitem_description_type":"Other"}]},"item_7_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"形態: カラー図版あり","subitem_description_type":"Other"}]},"item_7_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"Physical characteristics: Original contains color illustrations","subitem_description_type":"Other"}]},"item_7_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: PA1610095000","subitem_description_type":"Other"}]},"item_7_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_7_relation_25":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1038/srep04977"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/srep04977","subitem_relation_type_select":"DOI"}}]},"item_7_rights_28":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/"}]},"item_7_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_7_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"長岡技術科学大学"},{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"株式会社丸和栄養食品"},{"subitem_text_value":"株式会社コンフォーカルサイエンス"},{"subitem_text_value":"宇宙航空研究開発機構（JAXA)"},{"subitem_text_value":"宇宙航空研究開発機構（JAXA)"},{"subitem_text_value":"長岡技術科学大学"},{"subitem_text_value":"岩手医科大学"},{"subitem_text_value":"長岡技術科学大学"},{"subitem_text_value":"昭和大学"},{"subitem_text_value":"長岡技術科学大学"},{"subitem_text_value":"昭和大学"}]},"item_7_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Nagaoka University of Technology"},{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Maruwa Foods and Biosciences, Inc."},{"subitem_text_language":"en","subitem_text_value":"Confocal Science Inc."},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Nagaoka University of Technology"},{"subitem_text_language":"en","subitem_text_value":"Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Nagaoka University of Technology"},{"subitem_text_language":"en","subitem_text_value":"Showa University"},{"subitem_text_language":"en","subitem_text_value":"Nagaoka University of Technology"},{"subitem_text_language":"en","subitem_text_value":"Showa University"}]},"item_7_version_type_30":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"阪本, 泰光"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 義之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"飯塚, 一平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"館岡, 千佳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"六本木, 沙織"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤本, 真友"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊中, 浩治"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田仲, 広明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"正木, 美佳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"太田, 和敬"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡田, 宏文"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野中, 孝昌"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"森川, 康"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中村, 和郎 T."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小笠原, 渉"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 信忠"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Yasumitsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iizuka, Ippei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tateoka, Chika","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Roppongi, Saori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto, Mayu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inaka, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masaki, Mika","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohta, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okada, Hirofumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nonaka, Takamasa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morikawa, Yasushi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Kazuo  T.","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogasawara, Wataru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Nobutada","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"PA1610095000.pdf","filesize":[{"value":"6.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PA1610095000.pdf","url":"https://jaxa.repo.nii.ac.jp/record/22705/files/PA1610095000.pdf"},"version_id":"a584976a-c59c-4f6d-8f4d-ff63dfda4556"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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