{"created":"2023-06-20T15:11:25.333458+00:00","id":41071,"links":{},"metadata":{"_buckets":{"deposit":"a9628595-6838-4ed5-93cd-379c0a525861"},"_deposit":{"created_by":1,"id":"41071","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"41071"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00041071","sets":["1887:1893","1896:1898:1933:1934"]},"author_link":["501348","501349","501352","501357","501347","501356","501346","501351","501353","501345","501358","501363","501362","501354","501360","501350","501361","501344","501359","501355"],"item_3_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Study on biological effects of cosmic radiation and the development of radiation protection technology"}]},"item_3_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-10-20","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"388","bibliographicPageStart":"361","bibliographic_titles":[{"bibliographic_title":"宇宙開発事業団技術報告"},{"bibliographic_title":"NASDA Technical Memorandum","bibliographic_titleLang":"en"}]}]},"item_3_description_16":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"地球近傍の宇宙環境には多種の放射線が存在するが、その中で宇宙飛行士や搭載ペイロードにとって問題となるのは、プロトン以上の質量の高エネルギー粒子放射線(HZE)である。この実験では、宇宙放射線の中でも宇宙船の外壁を容易に貫通して船内に到達するHZE粒子や、この粒子線が船体やペイロードなどと相互作用して生ずる2次的な放射線を、飛跡検出材や熱蛍光性線量計で計測するとともに、これらの宇宙放射線の生物への影響を細胞レベルから個体レベルまでの異なった側面から研究、評価することを目的に行われた。宇宙実験に使用した装置は宇宙放射線モニタリングコンテナ2組とドシメータ13組であり、前者には、ハーツラスと呼ばれる固体飛跡検出材の間に生物試料を挟んだスタックを積層、充填し、後者には主としてハーツラスと熱蛍光線量計(TLD)を入れたものである。使用した生物試料は、放射線に感度の高いトウモロコシと大豆の種子、乾燥豊年エビ卵、DNA修復能を欠いた大腸菌突然変異株を中心に合計14種類のバクテリアを搭載した。これらの検出器および生物試料は、エンデバーでの宇宙実験終了後、約2週間で日本に返送され、物理的な線量解析と生物影響に関する実験を行った。TLDによる線量計測結果は、フッ化リチウム型TLDに関してはばらつきが大きく得られた価の信頼性が低かったが、ケイ酸マグネシウム型TLDは、被曝線量値が低いにもかかわらずばらつきの少ない良好な結果を与えることが解った。また、固体飛跡検出材の解析から得られた高エネルギー粒子線の線エネルギー付与率(LET)の分布は、IML-1ミッションやD-1のような同軌道のミッションで得られた結果と定性的にはよい一致を示したが、TLDと固体飛跡検出材両者の結果から推定された吸収線量率と線量当量率の比は、NASAジョンソ宇宙センターで計測された値と比較しかなり低い値を示した。生物試料に関し、2種の植物種子の体細胞突然変異率には、統計的に有為な変化は認め得なかったが、トウモロコシにくらべダイズがより放射線に敏感であることは相対的に確認することができた。豊年エビ卵は、試料の上下に置かれた飛跡検出材のエッチピット解析から、重粒子線に被曝した卵のみを弁別することが出来、幼生細胞に現われるピクノーシス頻度は地上群に比較し有為に上昇していることが解った。プラズミドDNApHY300PLKを保持した乾燥枯草菌胞子のテトラサイクリン耐性保持率は、地上対照試料では約90%であったが、フライト試料では約70%に低下しており、プラズミドDNA上に損傷が生じたか、宿主側の遺伝子に何らかの障害が出たことを示唆した。また、DNA修復能に関与する酵素活性を欠いた11種類の大腸菌突然変異株については、帰還後の生存率の変化について比較解析した結果、宇宙放射線からのDNA損傷の修復には、エキソヌクレアーゼ(特に3'→5')活性の寄与が大きく、紫外線損傷の修復系であるUVエンドヌクレアーゼ活性はほとんど寄与していないことがわかった。また、エキソヌクレアーゼ系を含んだ多重欠損突然変異株では、その多重度に依存して生存率が低下する事がわかった。これらの結果は宇宙放射線の生物影響がDNAのような分子レベルの領域に局在した、かなり顕著な作用を与えており、今後さらに詳細な実験や解析が心要なことを強く示唆している。","subitem_description_type":"Abstract"}]},"item_3_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"This experiment aims to measure cosmic radiation, especially Highly EnergiZed Electrons (HZE) that easily reaches the inside of a space ship by penetrating the outer wall, and secondary radiation generated from the synergetic effects between HZE and the ship body and payloads, using track detecting materials and a thermoluminescence dosimeter. This experiment also aims to investigate and evaluate the effects of the cosmic radiation on organisms at different levels such as cellular or individual level. The equipment used consists of two sets of cosmic radiation monitoring containers and 13 sets of dosimeters. The former was filled with piled stacks in which organic samples were sandwiched between solid state track-detecting materials called 'Hurtlus'. The latter includes the Hurtlus and ThermoLuminescence Dosimeters (TLD). The organic samples used include corn and soybean seeds that are sensitive to radiation, dried Artemia salina eggs, and 14 bacteria such as Escherichia coli mutants without DNA repair ability. These detecting devices and organic samples were returned to Japan for physical dose analysis and biological experiments about two weeks after the experiments in the Endeavor were over. Measuring doses with lithium fluoride TLD resulted in large dispersion with low reliability. However, measuring doses with magnesium silicate TLD showed good results with little dispersion in spite of low dose. Distribution of HZE's Liner Energy Transfer (LET) derived from solid track-detecting material analysis showed good qualitative agreement with the results of the same orbital experiments, such as IML-1 or D-1. However, the ratio of absorbed dose rate to dose equivalent rate, which was inferred from the results of the TLD and solid state track-detecting materials, was lower than that measured in the Johnson Space Center of NASA. The two kinds of plant seeds did not show any statistically significant change in somatic cell mutation: the soy bean seeds were confirmed to be more sensitive to radiation than corn seeds. Etch pit analysis of the track-detecting materials sandwiching the Artemia salina eggs allowed us to choose the eggs exposed to heavy ion beams. The exposed eggs showed that the picnosis frequency of juvenile cells was significantly higher than the ground samples. The tetracycline-resistant rate of dried Bacillus subtilis spores bearing plasmid DNA pHY300PLK was about 90 percent in the ground samples, while that of the flight samples was about 70 percent. This decrease suggests damages on the plasmid DNA or damaged host genes. The change in the survival rate of the 11 Escherichia coli mutants without enzyme activities involved in DNA repair was comparatively analyzed after returning to the Earth.","subitem_description_type":"Other"}]},"item_3_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0004115014","subitem_description_type":"Other"}]},"item_3_description_33":{"attribute_name":"レポート番号","attribute_value_mlt":[{"subitem_description":"レポート番号: NASDA-TMR-940002 V.1","subitem_description_type":"Other"}]},"item_3_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙開発事業団"}]},"item_3_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"National Space Development Agency of Japan (NASDA)"}]},"item_3_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1345-7888","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00364784","subitem_source_identifier_type":"NCID"}]},"item_3_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"宇宙開発事業団 宇宙実験グループ"},{"subitem_text_value":"早稲田大学"},{"subitem_text_value":"早稲田大学"},{"subitem_text_value":"日本大学"},{"subitem_text_value":"日本大学"},{"subitem_text_value":"理化学研究所"},{"subitem_text_value":"東京水産大学"},{"subitem_text_value":"国立ガンセンター"},{"subitem_text_value":"奈良県立医科大学"},{"subitem_text_value":"PL学園女子短期大学"}]},"item_3_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"National Space Development Agency of Japan Space Experiments Group"},{"subitem_text_language":"en","subitem_text_value":"Waseda University"},{"subitem_text_language":"en","subitem_text_value":"Waseda University"},{"subitem_text_language":"en","subitem_text_value":"Nihon University"},{"subitem_text_language":"en","subitem_text_value":"Nihon University"},{"subitem_text_language":"en","subitem_text_value":"Institute of Physical and Chemical Research"},{"subitem_text_language":"en","subitem_text_value":"Tokyo University of Fisheries"},{"subitem_text_language":"en","subitem_text_value":"National Cancer Research Center"},{"subitem_text_language":"en","subitem_text_value":"Nara Medical University"},{"subitem_text_language":"en","subitem_text_value":"PL Botanical Institute"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長岡, 俊治"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"道家, 忠義"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林, 孝義"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小倉, 紘一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山田, 博章"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高橋, 旦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石川, 雅紀"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田ノ岡, 宏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大西, 武雄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原田, 和樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagaoka, Shunji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Doke, Tadayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Takayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogura, Koichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Tan","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Masanobu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanooka, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Onishi, Takeo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harada, Kazuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-10"}],"displaytype":"detail","filename":"04115014.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"04115014.pdf","url":"https://jaxa.repo.nii.ac.jp/record/41071/files/04115014.pdf"},"version_id":"49ecf5b4-76a7-4553-9278-0f41b0281ed1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"宇宙放射線","subitem_subject_scheme":"Other"},{"subitem_subject":"宇宙飛行士","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線防御","subitem_subject_scheme":"Other"},{"subitem_subject":"生物影響","subitem_subject_scheme":"Other"},{"subitem_subject":"突然変異","subitem_subject_scheme":"Other"},{"subitem_subject":"大腸菌","subitem_subject_scheme":"Other"},{"subitem_subject":"枯草菌","subitem_subject_scheme":"Other"},{"subitem_subject":"プラスミド","subitem_subject_scheme":"Other"},{"subitem_subject":"高エネルギー粒子放射線","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線モニタリング","subitem_subject_scheme":"Other"},{"subitem_subject":"飛跡検出","subitem_subject_scheme":"Other"},{"subitem_subject":"スペースシャトル","subitem_subject_scheme":"Other"},{"subitem_subject":"修復","subitem_subject_scheme":"Other"},{"subitem_subject":"線量計測","subitem_subject_scheme":"Other"},{"subitem_subject":"植物種子","subitem_subject_scheme":"Other"},{"subitem_subject":"cosmic radiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"payload specialist","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radiation protection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biological effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mutation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Escherichia coli","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bacillus subtilis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"plasmid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HZE","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radiation monitoring","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"track detection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"space shuttle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"restoration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radiation dosimetry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"plant seed","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"technical report","resourceuri":"http://purl.org/coar/resource_type/c_18gh"}]},"item_title":"宇宙放射線の生物影響の検討と宇宙飛行士の放射線防御対策の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"宇宙放射線の生物影響の検討と宇宙飛行士の放射線防御対策の開発"}]},"item_type_id":"3","owner":"1","path":["1893","1934"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"41071","relation_version_is_last":true,"title":["宇宙放射線の生物影響の検討と宇宙飛行士の放射線防御対策の開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-20T20:27:20.531719+00:00"}