{"created":"2023-06-20T14:39:03.063039+00:00","id":5722,"links":{},"metadata":{"_buckets":{"deposit":"a518de7e-16dc-4e55-b260-d5eeb67d40a0"},"_deposit":{"created_by":1,"id":"5722","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5722"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00005722","sets":["1887:1893","9:789:998:1000"]},"author_link":["28152","28155","28153","28150","28151","28154"],"item_3_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Annual Report of \"Cbl-mediated ubiquitination downregulates the responsiveness of skeletal muscle cells to growth factors in space\" in FY18"}]},"item_3_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03-30","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"JAXA-SP-06-034","bibliographic_titles":[{"bibliographic_title":"宇宙航空研究開発機構特別資料: 平成18年度ISS科学プロジェクト室細胞生物学プロジェクト研究開発報告"},{"bibliographic_title":"JAXA Special Publication","bibliographic_titleLang":"en"}]}]},"item_3_description_16":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、これまで多く指摘されている宇宙空間での筋萎縮に注目し、微小重力による筋萎縮の新規メカニズムを実証し、その予防の可能性を探ることを目的としている。今年度は、ISS におけるフライト実験実施に向けた実験計画のベースライン化審査会を開催し、実験供試体の開発フェーズへの移行が承認された。これを踏まえ、サンプルホルダーや固定前処理器具の検証モデルを製作した。また、地上予備実験として、フライト実験でターゲットとしているCbl－b に関連したユビキチン－プロテアソーム系の上流部分の探索や過重力に対する影響について検討を行った。","subitem_description_type":"Abstract"}]},"item_3_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"This study is designed to elucidate molecular mechanism of microgravity-induced muscle atrophy and develop the countermeasures. In 2006, we had examination to evaluate whether our plan was suitable for space experiment in the International Space Station (ISS) and passed it. Then, we made mockup of equipments, such as sample holders and reagent suppliers, which will be used in ISS. In ground-based experiments, we examined mechanism of microgravity-induced expression of an ubiquitin ligase Cbl-b, a main regulator of muscle atrophy.","subitem_description_type":"Other"}]},"item_3_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0064959002","subitem_description_type":"Other"}]},"item_3_description_33":{"attribute_name":"レポート番号","attribute_value_mlt":[{"subitem_description":"レポート番号: JAXA-SP-06-034","subitem_description_type":"Other"}]},"item_3_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構"}]},"item_3_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Japan Aerospace Exploration Agency (JAXA)"}]},"item_3_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1349-113X","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11984031","subitem_source_identifier_type":"NCID"}]},"item_3_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部"},{"subitem_text_value":"宇宙航空研究開発機構宇宙科学研究本部"},{"subitem_text_value":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_3_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Institute of Health Biosciences, the University of Tokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (ISAS)(JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (ISAS)(JAXA)"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"二川, 健"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東端, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石岡, 憲昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nikawa, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashibata, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishioka, Noriaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-16"}],"displaytype":"detail","filename":"64959002.pdf","filesize":[{"value":"543.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"64959002.pdf","url":"https://jaxa.repo.nii.ac.jp/record/5722/files/64959002.pdf"},"version_id":"2d22eb64-04c8-46ca-8802-6debea0f02d6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ubiquitin ligase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"muscle atrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cbl-b","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"technical report","resourceuri":"http://purl.org/coar/resource_type/c_18gh"}]},"item_title":"細胞生物研究プロジェクト ユビキチンリガーゼCbl-b による筋萎縮の新規メカニズム: 平成18年度活動報告","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞生物研究プロジェクト ユビキチンリガーゼCbl-b による筋萎縮の新規メカニズム: 平成18年度活動報告"}]},"item_type_id":"3","owner":"1","path":["1000","1893"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"5722","relation_version_is_last":true,"title":["細胞生物研究プロジェクト ユビキチンリガーゼCbl-b による筋萎縮の新規メカニズム: 平成18年度活動報告"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T08:08:20.543018+00:00"}