Faculty of Integrated Arts and Sciences, University of Tokushima
Institute for Amphibian Biology, Graduate School of Science, Hiroshima University
Institute for Amphibian Biology, Graduate School of Science, Hiroshima University
Institute for Amphibian Biology, Graduate School of Science, Hiroshima University
Institute for Amphibian Biology, Graduate School of Science, Hiroshima University
Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology
Department of Biomedical Sciences, School of Life Science, Faculty of Medicine, Tottori University
Department of Neurobiology, Tokyo Metropolitan Institute of Medical Science
Faculty of Science, Kagoshima University
School of Health Science, Sapporo Medical University
Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)
Sanyo Women's College
出版者
宇宙航空研究開発機構宇宙科学研究本部
出版者（英）
Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)
雑誌名
宇宙利用シンポジウム
雑誌名(英)
Space Utilization Research: Proceedings of Space Utilization Symposium
The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan)
抄録（英）
Xenopus embryos raised under hypergravity condition develop a variety of abnormalities. Among them, head-defects such as microcephaly and cyclopia are the most common. Normal head formation is regulated by Wnt signaling. Inhibition of Wnt signaling causes head-defects in embryos, and ectopic activation of Wnt signaling induces extra body axis with head. Embryos are most sensitive to hypergravity within 30 min after fertilization, and activation of endogenous Wnt signaling occurs at almost the same time by cortical rotation which is sensitive to gravity. These facts suggest that the target of hypergravity might be Wnt signaling. In order to investigate this possibility, Wnt signaling activity in embryos raised under hypergravity conditions was analyzed by the measuring the expression of the Wnt-target genes. Quantitative RT-PCR revealed that the expression of some of Wnt-target genes was reduced in these embryos. This result strongly suggests that Wnt signaling is the target of the hypergravity derived head-defects in Xenopus embryos.
過重力下で見られるアフリカツメガエル頭部形成異常の解析
64297059.pdf
(499.02KB)
