WEKO3
アイテム
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骨の機械応答とosteocyte
https://jaxa.repo.nii.ac.jp/records/13436
https://jaxa.repo.nii.ac.jp/records/134364a5b7298-36f1-4015-9d6f-08ebea47c279
名前 / ファイル | ライセンス | アクション |
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63706060.pdf (206.5 kB)
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Item type | 会議発表論文 / Conference Paper(1) | |||||
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公開日 | 2015-03-26 | |||||
タイトル | ||||||
タイトル | 骨の機械応答とosteocyte | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | マウス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨芽細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 破骨細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 代謝 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 微小重力 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 重力効果 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨粗鬆症 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 活性 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 環境順化 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨ミネラル含量 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 遺伝子導入マウス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 尾部懸垂 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mouse | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | bone | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | osteoblast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | osteoclast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | osteocyte | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | metabolism | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | microgravity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | gravitational effect | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | osteoporosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | activity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | acclimatization | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | bone mineral content | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | transgenic mouse | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tail suspension | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
資源タイプ | conference paper | |||||
その他のタイトル(英) | ||||||
その他のタイトル | Osteocytes in the skeletal response to weightlessness | |||||
著者 |
池田, 恭治
× 池田, 恭治× 辰巳, 佐和子× 石井, 清朗× 小林, 利寛× 竹下, 淳× 網塚, 憲生× Li, Minqi× 河野, 憲二× 伊東, 昌子× Ikeda, Kyoji× Tatsumi, Sawako× Ishii, Kiyoaki× Kobayashi, Toshihiro× Takeshita, Sunao× Amizuka, Norio× Li, Minqi× Kono, Kenji× Ito, Masako |
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著者所属 | ||||||
国立長寿医療センター 運動器疾患研究部 | ||||||
著者所属 | ||||||
国立長寿医療センター 運動器疾患研究部 | ||||||
著者所属 | ||||||
国立長寿医療センター 運動器疾患研究部 | ||||||
著者所属 | ||||||
国立長寿医療センター 運動器疾患研究部 | ||||||
著者所属 | ||||||
国立長寿医療センター 運動器疾患研究部 | ||||||
著者所属 | ||||||
新潟大学 超域研究機構 | ||||||
著者所属 | ||||||
新潟大学 超域研究機構 | ||||||
著者所属 | ||||||
奈良先端科学技術大学院大学 バイオサイエンス研究科 | ||||||
著者所属 | ||||||
長崎大学 医学部・歯学部附属病院 | ||||||
著者所属(英) | ||||||
en | ||||||
National Center for Geriatrics and Gerontology Department of Bone and Joint Disease, Research Institute | ||||||
著者所属(英) | ||||||
en | ||||||
National Center for Geriatrics and Gerontology Department of Bone and Joint Disease, Research Institute | ||||||
著者所属(英) | ||||||
en | ||||||
National Center for Geriatrics and Gerontology Department of Bone and Joint Disease, Research Institute | ||||||
著者所属(英) | ||||||
en | ||||||
National Center for Geriatrics and Gerontology Department of Bone and Joint Disease, Research Institute | ||||||
著者所属(英) | ||||||
en | ||||||
National Center for Geriatrics and Gerontology Department of Bone and Joint Disease, Research Institute | ||||||
著者所属(英) | ||||||
en | ||||||
Niigata University Center for Transdisciplinary Research | ||||||
著者所属(英) | ||||||
en | ||||||
Niigata University Center for Transdisciplinary Research | ||||||
著者所属(英) | ||||||
en | ||||||
Nara Institute of Science and Technology Graduate School of Biological Sciences | ||||||
著者所属(英) | ||||||
en | ||||||
Nagasaki University Hospital of Medicine and Dentistry | ||||||
出版者 | ||||||
出版者 | 宇宙航空研究開発機構宇宙科学研究本部 | |||||
出版者(英) | ||||||
出版者 | Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS) | |||||
書誌情報 |
宇宙利用シンポジウム 第24回 平成19年度 en : Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium p. 234-235, 発行日 2008-03 |
|||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Bone metabolism is performed by bone-degrading osteoclasts and bone-building osteoblasts on bone surface. The osteocyte is a third cell type in bone that is derived from osteoblast lineage cells and embedded in the mineralized matrix. In order to delineate the in vivo function of the osteocyte, we have developed a transgenic mouse model that enables targeted ablation of osteocytes following a single injection of diphtheria toxin. Under normal loading condition, ablation of osteocytes caused aberrant activation of osteoclastic bone resorption with elevated expression of RANKL (Receptor Activator of NF-KB Ligand). In contrast, during unloading by tail suspension, the osteocyte-depleted mice were protected from disuse-induced bone atrophy. These data suggest that osteocytes play a pivotal role in sensing and/or transducing mechanical signals to adapt the structure and function of bone according to changing mechanical environments. | |||||
資料番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 資料番号: AA0063706060 |