WEKO3
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染色体切断の修復は細胞の低線量/低線量率γ線照射による影響を受ける
https://jaxa.repo.nii.ac.jp/records/13585
https://jaxa.repo.nii.ac.jp/records/1358543a33c99-7f31-4c58-a89e-c7a579cd6a3e
名前 / ファイル | ライセンス | アクション |
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63349087.pdf (305.4 kB)
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Item type | 会議発表論文 / Conference Paper(1) | |||||
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公開日 | 2015-03-26 | |||||
タイトル | ||||||
タイトル | 染色体切断の修復は細胞の低線量/低線量率γ線照射による影響を受ける | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 染色体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 放射線影響 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ガンマ線 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 培養細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 遺伝子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 酵素 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 生物学的影響 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 航空宇宙環境 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 血液細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 2重鎖切断 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DSB | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 非相同末端結合 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | EJ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 相同組替え | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HR | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | chromosome | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | radiation effect | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | gamma ray | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cultured cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | gene | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | enzyme | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | biological effect | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | aerospace environment | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | blood cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | double-strand break | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | DSB | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | end-joining | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | EJ | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | homologous recombination | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | HR | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
資源タイプ | conference paper | |||||
その他のタイトル(英) | ||||||
その他のタイトル | Repair of DSB at a specific site of chromosome: Influence of low-dose/low-dose-rate gamma-rays | |||||
著者 |
谷田貝, 文夫
× 谷田貝, 文夫× 梅林, 志浩× 岩木, 正哉× 本間, 正充× 鈴木, 雅雄× 石岡, 憲昭× 嶋津, 徹× 鈴木, ひろみ× Yatagai, Fumio× Umebayashi, Yukihiro× Iwaki, Masaya× Honma, Masamitsu× Suzuki, Masao× Ishioka, Noriaki× Shimazu, Toru× Suzuki, Hiromi |
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著者所属 | ||||||
理化学研究所 | ||||||
著者所属 | ||||||
理化学研究所 | ||||||
著者所属 | ||||||
理化学研究所 | ||||||
著者所属 | ||||||
国立医薬品食品衛生研究所 | ||||||
著者所属 | ||||||
放射線医学総合研究所 | ||||||
著者所属 | ||||||
宇宙航空研究開発機構 宇宙科学研究本部 | ||||||
著者所属 | ||||||
日本宇宙フォーラム | ||||||
著者所属 | ||||||
日本宇宙フォーラム | ||||||
著者所属(英) | ||||||
en | ||||||
Institute of Physical and Chemical Research | ||||||
著者所属(英) | ||||||
en | ||||||
Institute of Physical and Chemical Research | ||||||
著者所属(英) | ||||||
en | ||||||
Institute of Physical and Chemical Research | ||||||
著者所属(英) | ||||||
en | ||||||
National Institute of Health Sciences | ||||||
著者所属(英) | ||||||
en | ||||||
National Institute of Radiological Sciences | ||||||
著者所属(英) | ||||||
en | ||||||
Japan Aerospace Exploration Agency Institute of Space and Astronautical Science | ||||||
著者所属(英) | ||||||
en | ||||||
Japan Space Forum | ||||||
著者所属(英) | ||||||
en | ||||||
Japan Space Forum | ||||||
出版者 | ||||||
出版者 | 宇宙航空研究開発機構宇宙科学研究本部 | |||||
出版者(英) | ||||||
出版者 | Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS) | |||||
書誌情報 |
宇宙利用シンポジウム 第23回 平成18年度 en : Space Utilization Research: Proceedings of the Twenty-third Space Utilization Symposium p. 305-308, 発行日 2007-03 |
|||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | DSB (Double Strand Break) was introduced by the I-Sce I expression vector, pCMV3xnls-I-Sce I. Repair of DSB at the I-SceI site inserted at intron 4 of the tk+ allele in human lymphoblstoid TK6 cell line, TSCE5, was measured by induction of TK-deficient mutants. Similarly we also measured the revertants due to such repair in its compound heterozygote (tk-/-) cell line, TSCER2, which carried an additional point-mutation in exon 5. The former and later measurements reflect the DSB repair efficiency due to DNA End-Joining (EJ) and Homologous Recombination (HR), respectively. The pre-treatment, gamma-irradiation with 30 mGy at a dose rate of 1.2 mGy/hr did not influence the EJ repair efficiency but enhanced HR repair efficiency, approximately 50 percent. The I-SceI digestion followed by much lower dose(/dose-rate) gamma-irradiation (8.5 mGy at 0.125 mGy/hr) during the incubation tesulted in a similar tendency of HR enhancement (approximately 50 percent). This kind of treatment, introducing the chromosome break by the restriction enzyme, can be regarded as a useful approach for elucidating the influences of space environments on the DSB repair. | |||||
資料番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 資料番号: AA0063349087 |