WEKO3
アイテム
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5型アデニル酸シクラーゼ刺激薬は微小重力下での自律神経調節障害の治療薬になりうるか?
https://jaxa.repo.nii.ac.jp/records/13448
https://jaxa.repo.nii.ac.jp/records/134480a8f47a3-b478-4fdd-86b7-971b441a5d94
名前 / ファイル | ライセンス | アクション |
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63706072.pdf (213.3 kB)
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Item type | 会議発表論文 / Conference Paper(1) | |||||
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公開日 | 2015-03-26 | |||||
タイトル | ||||||
タイトル | 5型アデニル酸シクラーゼ刺激薬は微小重力下での自律神経調節障害の治療薬になりうるか? | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 自律神経系 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 交感神経系 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 刺激薬 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5型アデニル酸シクラーゼ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | AC5 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NKH477 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 放物線飛行 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 薬 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | マウス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 微小重力 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心電図 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | パワースペクトル | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 自律神経調節 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 遺伝子導入マウス | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | autonomic nervous system | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | sympathetic nervous system | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | stimulant | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | type 5 adenylyl cyclase | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | AC5 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | NKH477 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | parabolic flight | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | drug | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mouse | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | microgravity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | electrocardiography | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | power spectrum | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | autonomic regulation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | transgenic mouse | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
資源タイプ | conference paper | |||||
その他のタイトル(英) | ||||||
その他のタイトル | Type 5 adenylyl cyclase stimulater might be useful for the treatment of autonomic dysfunction after spaceflight? | |||||
著者 |
奥村, 敏
× 奥村, 敏× Bai, Yunzhe× 黒谷, 玲子× 佐藤, 元彦× 南沢, 享× 石川, 義弘× Okumura, Satoshi× Bai, Yunzhe× Kurotani, Reiko× Sato, Motohiko× Minamisawa, Susumu× Ishikawa, Yoshihiro |
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著者所属 | ||||||
横浜市立大学 大学院医学研究科 | ||||||
著者所属 | ||||||
横浜市立大学 大学院医学研究科 | ||||||
著者所属 | ||||||
横浜市立大学 大学院医学研究科 | ||||||
著者所属 | ||||||
横浜市立大学 大学院医学研究科 | ||||||
著者所属 | ||||||
横浜市立大学 大学院医学研究科 | ||||||
著者所属 | ||||||
横浜市立大学 大学院医学研究科 | ||||||
著者所属(英) | ||||||
en | ||||||
Yokohama City University Graduate School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Yokohama City University Graduate School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Yokohama City University Graduate School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Yokohama City University Graduate School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Yokohama City University Graduate School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Yokohama City University Graduate School of Medicine | ||||||
出版者 | ||||||
出版者 | 宇宙航空研究開発機構宇宙科学研究本部 | |||||
出版者(英) | ||||||
出版者 | Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS) | |||||
書誌情報 |
宇宙利用シンポジウム 第24回 平成19年度 en : Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium p. 267-268, 発行日 2008-03 |
|||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | We have demonstrated that type 5 Adenylyl Cyclase (AC5), a major cardiac AC isoform, plays a major role in determining the magnitude of cardiac response to autonomic regulation under microgravity using transgenic mouse models with either disrupted or overexpressed AC5 in the heart (Space Utiliz Res 23, 267-268, 2007). To test the hypothesis that specific AC5 stimulator (NKH477) may be useful for the treatment of autonomic dysfunction after spaceflight, we implanted osmotic mini-pump (1 mg/kg/day) in wild-type mice and analyzed heart rate variability during parabolic flight. The standard deviation of normal R-R intervals, a marker of total autonomic variability, was increased under microgravity in each group. However, the magnitude of the increase was much smaller in NKH477 group. We also examined the ratio between Low Frequency (LF) and High Frequency (HF), a marker of sympathetic activity, and normalized HF, a marker of parasympathetic activity, and found that these parameters in NKH477 group were similar to those in cardiac-specific AC5 overexpression mice we have previously examined. These results indicate that NKH477 could be able to stabilize the changes in autonomic indexes in response to microgravity, suggesting that it may be a useful for the treatment of autonomic dysfunction after spaceflight. | |||||
資料番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 資料番号: AA0063706072 |