WEKO3
アイテム
{"_buckets": {"deposit": "2912bdae-1a16-47dd-a0f2-c28dda59be89"}, "_deposit": {"created_by": 1, "id": "22705", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "22705"}, "status": "published"}, "_oai": {"id": "oai:jaxa.repo.nii.ac.jp:00022705", "sets": ["1888"]}, "author_link": ["213076", "213050", "213077", "213071", "213070", "213075", "213065", "213058", "213062", "213073", "213080", "213072", "213060", "213064", "213049", "213059", "213055", "213079", "213051", "213066", "213053", "213061", "213057", "213069", "213052", "213056", "213067", "213074", "213078", "213068", "213054", "213063"], "item_7_biblio_info_10": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-05-15", "bibliographicIssueDateType": "Issued"}, "bibliographicVolumeNumber": "4", "bibliographic_titles": [{}, {"bibliographic_title": "Scientific Reports", "bibliographic_titleLang": "en"}]}]}, "item_7_description_17": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "The dipeptidyl aminopeptidase BII (DAP BII) belongs to a serine peptidase family, S46. The amino acid sequence of the catalytic unit of DAP BII exhibits significant similarity to those of clan PA endopeptidases, such as chymotrypsin. However, the molecular mechanism of the exopeptidase activity of family S46 peptidase is unknown. Here, we report crystal structures of DAP BII. DAP BII contains a peptidase domain including a typical double b-barrel fold and previously unreported a-helical domain. The structures of peptide complexes revealed that the a-helical domain covers the active-site cleft and the side chain of Asn330 in the domain forms hydrogen bonds with the N-terminus of the bound peptide. These observations indicate that the a-helical domain regulates the exopeptidase activity of DAP BII. Because S46 peptidases are not found in mammals, we expect that our study will be useful for the design of specific inhibitors of S46 peptidases from pathogens.", "subitem_description_type": "Other"}]}, "item_7_description_18": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "形態: カラー図版あり", "subitem_description_type": "Other"}]}, "item_7_description_19": {"attribute_name": "内容記述(英)", "attribute_value_mlt": [{"subitem_description": "Physical characteristics: Original contains color illustrations", "subitem_description_type": "Other"}]}, "item_7_description_32": {"attribute_name": "資料番号", "attribute_value_mlt": [{"subitem_description": "資料番号: PA1610095000", "subitem_description_type": "Other"}]}, "item_7_publisher_9": {"attribute_name": "出版者(英)", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group"}]}, "item_7_relation_25": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "info:doi/10.1038/srep04977"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1038/srep04977", "subitem_relation_type_select": "DOI"}}]}, "item_7_rights_28": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images in this article are included in the article\u0027s Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/"}]}, "item_7_source_id_21": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "ISSN"}]}, "item_7_text_35": {"attribute_name": "JAXAカテゴリ", "attribute_value_mlt": [{"subitem_text_value": "JAXAカテゴリ: 学術雑誌論文"}]}, "item_7_text_36": {"attribute_name": "JAXAカテゴリ2", "attribute_value_mlt": [{"subitem_text_value": "JAXAカテゴリ2: TP"}]}, "item_7_text_37": {"attribute_name": "管理者メモ", "attribute_value_mlt": [{"subitem_text_value": "管理者メモ: 旧URL: http://www.nature.com/search?q=S46%20Peptidases%20are%20the%20First%20Exopeptidases%20to%20be%20Members%20of%20Clan%20PA\u0026sp-x-9=cat\u0026sp_a=sp1001702d\u0026sp_p_1=phrase\u0026sp_sfv1_field=subject%7Cujournal\u0026sp_t=results\u0026sp_x_1=ujournal\u0026submit=go"}]}, "item_7_text_43": {"attribute_name": "DSpaceコレクション番号", "attribute_value_mlt": [{"subitem_text_value": "DSpaceコレクション番号: 10"}]}, "item_7_text_6": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学"}, {"subitem_text_value": "長岡技術科学大学"}, {"subitem_text_value": "岩手医科大学"}, {"subitem_text_value": "岩手医科大学"}, {"subitem_text_value": "岩手医科大学"}, {"subitem_text_value": "岩手医科大学"}, {"subitem_text_value": "株式会社丸和栄養食品"}, {"subitem_text_value": "株式会社コンフォーカルサイエンス"}, {"subitem_text_value": "宇宙航空研究開発機構(JAXA)"}, {"subitem_text_value": "宇宙航空研究開発機構(JAXA)"}, {"subitem_text_value": "長岡技術科学大学"}, {"subitem_text_value": "岩手医科大学"}, {"subitem_text_value": "長岡技術科学大学"}, {"subitem_text_value": "昭和大学"}, {"subitem_text_value": "長岡技術科学大学"}, {"subitem_text_value": "昭和大学"}]}, "item_7_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Iwate Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Nagaoka University of Technology"}, {"subitem_text_language": "en", "subitem_text_value": "Iwate Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Iwate Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Iwate Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Iwate Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Maruwa Foods and Biosciences, Inc."}, {"subitem_text_language": "en", "subitem_text_value": "Confocal Science Inc."}, {"subitem_text_language": "en", "subitem_text_value": "Japan Aerospace Exploration Agency (JAXA)"}, {"subitem_text_language": "en", "subitem_text_value": "Japan Aerospace Exploration Agency (JAXA)"}, {"subitem_text_language": "en", "subitem_text_value": "Nagaoka University of Technology"}, {"subitem_text_language": "en", "subitem_text_value": "Iwate Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Nagaoka University of Technology"}, {"subitem_text_language": "en", "subitem_text_value": "Showa University"}, {"subitem_text_language": "en", "subitem_text_value": "Nagaoka University of Technology"}, {"subitem_text_language": "en", "subitem_text_value": "Showa University"}]}, "item_7_version_type_30": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "阪本, 泰光"}], "nameIdentifiers": [{"nameIdentifier": "213049", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木, 義之"}], "nameIdentifiers": [{"nameIdentifier": "213050", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "飯塚, 一平"}], "nameIdentifiers": [{"nameIdentifier": "213051", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "館岡, 千佳"}], "nameIdentifiers": [{"nameIdentifier": "213052", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "六本木, 沙織"}], "nameIdentifiers": [{"nameIdentifier": "213053", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤本, 真友"}], "nameIdentifiers": [{"nameIdentifier": "213054", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "伊中, 浩治"}], "nameIdentifiers": [{"nameIdentifier": "213055", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "田仲, 広明"}], "nameIdentifiers": [{"nameIdentifier": "213056", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "正木, 美佳"}], "nameIdentifiers": [{"nameIdentifier": "213057", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "太田, 和敬"}], "nameIdentifiers": [{"nameIdentifier": "213058", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岡田, 宏文"}], "nameIdentifiers": [{"nameIdentifier": "213059", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "野中, 孝昌"}], "nameIdentifiers": [{"nameIdentifier": "213060", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "森川, 康"}], "nameIdentifiers": [{"nameIdentifier": "213061", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中村, 和郎 T."}], "nameIdentifiers": [{"nameIdentifier": "213062", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小笠原, 渉"}], "nameIdentifiers": [{"nameIdentifier": "213063", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "田中, 信忠"}], "nameIdentifiers": [{"nameIdentifier": "213064", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakamoto, Yasumitsu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213065", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Yoshiyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213066", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iizuka, Ippei", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213067", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tateoka, Chika", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213068", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Roppongi, Saori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213069", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimoto, Mayu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213070", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inaka, Koji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213071", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Hiroaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213072", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masaki, Mika", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213073", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohta, Kazunori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213074", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Hirofumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213075", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nonaka, Takamasa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213076", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morikawa, Yasushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213077", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Kazuo T.", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213078", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogasawara, Wataru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213079", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Nobutada", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213080", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-01-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PA1610095000.pdf", "filesize": [{"value": "6.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 6700000.0, "url": {"label": "PA1610095000.pdf", "url": "https://jaxa.repo.nii.ac.jp/record/22705/files/PA1610095000.pdf"}, "version_id": "a584976a-c59c-4f6d-8f4d-ff63dfda4556"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "S46 Peptidases are the First Exopeptidases to be Members of Clan PA", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "S46 Peptidases are the First Exopeptidases to be Members of Clan PA", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["1888"], "permalink_uri": "https://jaxa.repo.nii.ac.jp/records/22705", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-06-13"}, "publish_date": "2016-06-13", "publish_status": "0", "recid": "22705", "relation": {}, "relation_version_is_last": true, "title": ["S46 Peptidases are the First Exopeptidases to be Members of Clan PA"], "weko_shared_id": -1}
S46 Peptidases are the First Exopeptidases to be Members of Clan PA
https://jaxa.repo.nii.ac.jp/records/22705
https://jaxa.repo.nii.ac.jp/records/227052f6ae4c5-aec9-4cb1-96df-d8a80ffe87ad
名前 / ファイル | ライセンス | アクション |
---|---|---|
PA1610095000.pdf (6.7 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2016-06-13 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | S46 Peptidases are the First Exopeptidases to be Members of Clan PA | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
阪本, 泰光
× 阪本, 泰光× 鈴木, 義之× 飯塚, 一平× 館岡, 千佳× 六本木, 沙織× 藤本, 真友× 伊中, 浩治× 田仲, 広明× 正木, 美佳× 太田, 和敬× 岡田, 宏文× 野中, 孝昌× 森川, 康× 中村, 和郎 T.× 小笠原, 渉× 田中, 信忠× Sakamoto, Yasumitsu× Suzuki, Yoshiyuki× Iizuka, Ippei× Tateoka, Chika× Roppongi, Saori× Fujimoto, Mayu× Inaka, Koji× Tanaka, Hiroaki× Masaki, Mika× Ohta, Kazunori× Okada, Hirofumi× Nonaka, Takamasa× Morikawa, Yasushi× Nakamura, Kazuo T.× Ogasawara, Wataru× Tanaka, Nobutada |
|||||
著者所属 | ||||||
岩手医科大学 | ||||||
著者所属 | ||||||
長岡技術科学大学 | ||||||
著者所属 | ||||||
岩手医科大学 | ||||||
著者所属 | ||||||
岩手医科大学 | ||||||
著者所属 | ||||||
岩手医科大学 | ||||||
著者所属 | ||||||
岩手医科大学 | ||||||
著者所属 | ||||||
株式会社丸和栄養食品 | ||||||
著者所属 | ||||||
株式会社コンフォーカルサイエンス | ||||||
著者所属 | ||||||
宇宙航空研究開発機構(JAXA) | ||||||
著者所属 | ||||||
宇宙航空研究開発機構(JAXA) | ||||||
著者所属 | ||||||
長岡技術科学大学 | ||||||
著者所属 | ||||||
岩手医科大学 | ||||||
著者所属 | ||||||
長岡技術科学大学 | ||||||
著者所属 | ||||||
昭和大学 | ||||||
著者所属 | ||||||
長岡技術科学大学 | ||||||
著者所属 | ||||||
昭和大学 | ||||||
著者所属(英) | ||||||
en | ||||||
Iwate Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Nagaoka University of Technology | ||||||
著者所属(英) | ||||||
en | ||||||
Iwate Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Iwate Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Iwate Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Iwate Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Maruwa Foods and Biosciences, Inc. | ||||||
著者所属(英) | ||||||
en | ||||||
Confocal Science Inc. | ||||||
著者所属(英) | ||||||
en | ||||||
Japan Aerospace Exploration Agency (JAXA) | ||||||
著者所属(英) | ||||||
en | ||||||
Japan Aerospace Exploration Agency (JAXA) | ||||||
著者所属(英) | ||||||
en | ||||||
Nagaoka University of Technology | ||||||
著者所属(英) | ||||||
en | ||||||
Iwate Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Nagaoka University of Technology | ||||||
著者所属(英) | ||||||
en | ||||||
Showa University | ||||||
著者所属(英) | ||||||
en | ||||||
Nagaoka University of Technology | ||||||
著者所属(英) | ||||||
en | ||||||
Showa University | ||||||
出版者(英) | ||||||
出版者 | Nature Publishing Group | |||||
書誌情報 |
en : Scientific Reports 巻 4, 発行日 2014-05-15 |
|||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | The dipeptidyl aminopeptidase BII (DAP BII) belongs to a serine peptidase family, S46. The amino acid sequence of the catalytic unit of DAP BII exhibits significant similarity to those of clan PA endopeptidases, such as chymotrypsin. However, the molecular mechanism of the exopeptidase activity of family S46 peptidase is unknown. Here, we report crystal structures of DAP BII. DAP BII contains a peptidase domain including a typical double b-barrel fold and previously unreported a-helical domain. The structures of peptide complexes revealed that the a-helical domain covers the active-site cleft and the side chain of Asn330 in the domain forms hydrogen bonds with the N-terminus of the bound peptide. These observations indicate that the a-helical domain regulates the exopeptidase activity of DAP BII. Because S46 peptidases are not found in mammals, we expect that our study will be useful for the design of specific inhibitors of S46 peptidases from pathogens. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 形態: カラー図版あり | |||||
内容記述(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Physical characteristics: Original contains color illustrations | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-2322 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1038/srep04977 | |||||
関連名称 | info:doi/10.1038/srep04977 | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資料番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 資料番号: PA1610095000 |