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ヒト臓器・組織置換マウス等を用いた宇宙放射線の人体および継世代リスクの基礎評価
https://jaxa.repo.nii.ac.jp/records/13260
https://jaxa.repo.nii.ac.jp/records/13260e6f4bf67-4e59-44cb-8f88-616ea2563d3a
名前 / ファイル | ライセンス | アクション |
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Item type | 会議発表論文 / Conference Paper(1) | |||||
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公開日 | 2015-03-26 | |||||
タイトル | ||||||
タイトル | ヒト臓器・組織置換マウス等を用いた宇宙放射線の人体および継世代リスクの基礎評価 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Space Radiation, Neutron, Human Thyroid Gland, SCID Mice, Microsatellite Mutation, Leukemia, F(sub 1) Progeny | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
資源タイプ | conference paper | |||||
その他のタイトル(英) | ||||||
その他のタイトル | Risk of cosmic radiation on human organs and tissues maintained in SCID mice and transgenerational effects | |||||
著者 |
野村, 大成
× 野村, 大成× 梁, 治子× 足立, 成基× 中島, 裕夫× 本行, 忠志× 藤川, 和男× 伊藤, 哲夫× 松塚, 文夫× Nomura, Taisei× Ryo, Haruko× Adachi, Shigeki× Nakajima, Hiroo× Hongyo, Tadashi× Fujikawa, Kazuo× Itoh, Tetsuo× Matsuzuka, Fumio |
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著者所属 | ||||||
医薬基盤研究所 | ||||||
著者所属 | ||||||
医薬基盤研究所 | ||||||
著者所属 | ||||||
医薬基盤研究所 | ||||||
著者所属 | ||||||
大阪大学医学系研究科 | ||||||
著者所属 | ||||||
大阪大学医学系研究科 | ||||||
著者所属 | ||||||
近畿大学理工学部 | ||||||
著者所属 | ||||||
近畿大学理工学部 | ||||||
著者所属 | ||||||
神戸隈病院 | ||||||
著者所属(英) | ||||||
en | ||||||
National Institute of Biomedical Innovation | ||||||
著者所属(英) | ||||||
en | ||||||
National Institute of Biomedical Innovation | ||||||
著者所属(英) | ||||||
en | ||||||
National Institute of Biomedical Innovation | ||||||
著者所属(英) | ||||||
en | ||||||
Graduate School of Medicine, Osaka University | ||||||
著者所属(英) | ||||||
en | ||||||
Graduate School of Medicine, Osaka University | ||||||
著者所属(英) | ||||||
en | ||||||
School of Science and Engineering, Kinki University | ||||||
著者所属(英) | ||||||
en | ||||||
School of Science and Engineering, Kinki University | ||||||
著者所属(英) | ||||||
en | ||||||
Kobe Kuma Hospital | ||||||
出版者 | ||||||
出版者 | 宇宙航空研究開発機構宇宙科学研究本部 | |||||
出版者(英) | ||||||
出版者 | Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA) | |||||
書誌情報 |
宇宙利用シンポジウム en : Space Utilization Research: Proceedings of Space Utilization Symposium 巻 25, 発行日 2009-03 |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス) | |||||
会議概要(会議名, 開催地, 会期, 主催者等)(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan) | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | To study the risk of cosmic radiation, two projects, effects on human organs and tissues maintained in super-SCID mice and transgenerational effects in the offspring of mice exposed to radiation were carried out;. Morphological and functional (hormone secretion) changes and/or mutations were induced in human thyroid tissues by high doses and high dose rate of X- and gamma-rays (9-33 Gy) and reactor neutron (0.2 Gy x 6), but not by same doses with low dose-rate of gamma-rays, showing apparent dose rate effects in human thyroid tissues. Neutron (0.2 Gy x 4) induced bigger changes in gene expression than 2 Gy of gamma-rays, suggesting high RBE of neutron. Microsatellite mutations and lymphocytic leukemia were induced dose-dependently in the offspring of N5 male mice exposed to 0.2 and 0.4 Gy of neutron. The incidence was 10 folds higher than our former X-ray and gamma-ray studies, again suggesting high RBE. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 形態: カラー図版あり | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10324210 | |||||
資料番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 資料番号: AA0064297016 |